73148-41-1

Basic information

• Product Name: 2-Butenoic acid, 3-[[(1R)-1-phenylethyl]amino]-, ethyl ester, (2Z)-
• Synonyms: 2-Butenoic acid,3-[[(1R)-1-phenylethyl]amino]-,ethyl ester,(2Z)
• CAS NO: 73148-41-1
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.31
• Mol File: 73148-41-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-[[(1R)-1-phenylethyl]amino]-, ethyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-[[(1R)-1-phenylethyl]amino]-, ethyl ester, (2Z)-(73148-41-1)
• EPA Substance Registry System: 2-Butenoic acid, 3-[[(1R)-1-phenylethyl]amino]-, ethyl ester, (2Z)-(73148-41-1)

Safety Data

• Hazardous Substances Data: 73148-41-1(Hazardous Substances Data)

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 141-97-9 ethyl acetoacetate 
• 56424-40-9 Isopropylidene-((R)-1-phenyl-ethyl)-amine 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 184888-43-5 (R)-(1-phenylethyl)carbamic acid tert-butyl ester 
• 290357-68-5 ethyl 2-[(1S)-1-(nitromethyl)ethyl]-3-[(1R)-(1-phenylethyl)amino]but-2-enoate 
• 103123-52-0 (R,R)-ethyl 3-butanoate 

Relevant articles and documents

Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1- phenylethyl)thioxotetrahydropyrimidin-4(1H)-ones: A stereochemical perspective from endo and exocyclic chiral centres

Diastereoselective syntheses of 3-aryl-(S/R)-6-methyl-1-[(S/R)-1- phenylethyl)]-2-thioxotetrahydro pyrimidin-4(1H)-ones were achieved in good yields by the condensation of aryl isothiocyanates with ethyl 3-(1-phenylethylamino)butanoate in a one-pot reaction. Benzylation of these substrates illustrated that the orientations of the exocylic and endocylic groups determine the stereochemical outcome of the product formed.

A general and efficient method for the preparation of β-enamino ketones and esters catalyzed by indium tribromide

A variety of β-enamino ketones and esters have been synthesized in high to exellent yields by reacting β-dicarbonyl compounds with amines in the presence of a catalytic amount of indium tribromide. The reaction proceeds smoothly at room temperature in a short reaction time under solvent-free conditions.

Enantioselective Michael reactions of chiral secondary enaminoesters with 2-substituted nitroethylenes. Syntheses of trans,trans-2,4-disubstituted pyrrolidine-3-carboxylates

The Michael reaction of chiral 3-substituted secondary enaminoesters with 2-substituted nitroethylenes leads to (Z)-adducts, with good to excellent diastereoselectivity. The nitro group of these adducts was catalytically reduced to give, after cyclization and chiral amine elimination, pyrrolines or pyrrolidines after further reduction. In particular, the syntheses of ethyl (2R,3S,4S)-2,4-dimethylpyrrolidine-3-carboxylate and ethyl (2R,3R,4S)-2-(4-methoxyphenyl)-4-(3,4-(methylenedioxy)phenyl)pyrrolidine-3-ca rboxylate are described.