103123-52-0

Upstream product

• 73148-41-1 ethyl (Z)-(R)-3-(1-phenyl-ethylamino)but-2-enoate 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 141-97-9 ethyl acetoacetate 
• 956104-76-0 C₁₄H₁₉NO₂ 
• 623-70-1 ethyl (E)-crotonate 
• 204587-98-4 (3R,1'R)-3-(N-α-methylbenzyl-N'-benzylamino)-butanoate 

Downstream Products

• 884318-83-6 (2S,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate 
• 884318-84-7 (2R,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate 
• 884318-73-4 ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate 

Relevant academic research and scientific papers

Diastereo and Enantioselective Entry to β-Amino Esters by Hydride Reduction of Homochiral β-Enamino Esters.

The reduction of homochiral β-enamino esters 1 with sodium triacetoxyborohydride, which occurs with good diastereo- and enantioselectivity in the β-amino esters 2, is described.The procedure allows a straightforward preparation of compounds with known bio

Synthetic method of dolutegravir key intermediate (R)-3-aminobutanol

The invention discloses a synthetic method of dolutegravir key intermediate (R)-3-aminobutanol. The synthesis route is disclosed in the invention, and is suitable for industrialized large-scale production of (R)-3-aminobutanol; product optical purity is increased effectively; using of raw materials dangerous in operation is avoided; product yield is extremely high; and the synthetic method is suitable for industrialized popularization and application.

Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1- phenylethyl)thioxotetrahydropyrimidin-4(1H)-ones: A stereochemical perspective from endo and exocyclic chiral centres

Diastereoselective syntheses of 3-aryl-(S/R)-6-methyl-1-[(S/R)-1- phenylethyl)]-2-thioxotetrahydro pyrimidin-4(1H)-ones were achieved in good yields by the condensation of aryl isothiocyanates with ethyl 3-(1-phenylethylamino)butanoate in a one-pot reaction. Benzylation of these substrates illustrated that the orientations of the exocylic and endocylic groups determine the stereochemical outcome of the product formed.

Diastereoselective synthesis of aziridine esters via amino selanyl esters

A synthesis of aziridine esters based on the cyclisation of amino selanyl esters induced by the selanyl group activation was developed with either the Meerwein salt or NBS. Two asymmetric approaches are proposed: the diastereoselective reductions of α-sel

Stereoselective reduction of enantiopure β-enamino esters by hydride: A convenient synthesis of both enantiopure β-amino esters

The reduction of enantiopure β-enamino esters 1 with sodium triacetoxyborohydride in acetic acid is described. This occurs with good diastereo- and enantioselectivity to yield β-amino esters 2 and 3 (after hydrogenolysis of the N-chiral group). A model is