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Fenticonazole nitrate 73151-29-8
Cas No: 73151-29-8
No Data 1 Kilogram 500 Kilogram/Month Luyunjia Chemistry Xiamen Limited Contact Supplier
High quality Fenticonazole Nitrate supplier in China
Cas No: 73151-29-8
No Data 1 Kilogram 200 Metric Ton/Year Simagchem Corporation Contact Supplier
High purity Various Specifications Fenticonazole nitrate CAS:73151-29-8
Cas No: 73151-29-8
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Manufacturer supply Fenticonazole nitrate CAS 73151-29-8 of EP/USP standard
Cas No: 73151-29-8
USD $ 400.0-700.0 / Kilogram 1 Kilogram 1500 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High purity Fenticonazole nitrate CAS No.:73151-29-8
Cas No: 73151-29-8
USD $ 2.0-2.0 / Kilogram 1 Kilogram 1 Metric Ton/Month Hangzhou Think Chemical Co. Ltd Contact Supplier
Factory Supply Fenticonazole Nitrate
Cas No: 73151-29-8
No Data 1 1 Ality Chemical Corporation Contact Supplier
High Quality 99% Fenticonazole nitrate 73151-29-8 ISO Producer
Cas No: 73151-29-8
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Fenticonazole nitrate
Cas No: 73151-29-8
USD $ 5.0-10.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
High purity Fenticonazole nitrate 98% TOP1 supplier in China
Cas No: 73151-29-8
USD $ 1.0-2.0 / Gram 1 Gram 100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Fenticonazole nitrate
Cas No: 73151-29-8
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier

73151-29-8 Usage


Fenticonazole nitrate is an antifungal imidazole derivative reported to be more effective than other imidazole antifungals such as miconazole, clotrimazole and econazole. In addition to its potent, broad-spectrum fungicidal activity, fenticonazole is also active against some Gram-positive bacteria.


Fenticonazole is an imidazole with antimicrobial activity. It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml. It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml. Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).

Chemical Properties

Off-White Solid


Recordati (Italy)


Broad spectrum antimycotic; also active as antibacterial. Antifungal (topical).


ChEBI: A racemate comprising equimolar amounts of (R)- and (S)-fenticonazole nitrate. Used for the treatment of vaginal candidiasis.

Manufacturing Process

1-(2',4'-Dichlorophenyl)-2-chloroethanol:49.5 g of sodium borohydride were added slowly and in small parts to a suspension of 233 g of 1-(1'-hydroxy-2'-chloroethyl)-2,4-dichlorobenzene in 1 liter of methanol stirred at room temperature. The solution thus obtained was stirred at room temperature for a further two hours, and it was then poured into 1 liter of 5 N hydrochloric acid cooled with ice. After extraction with ethyl acetate or chloroform, the extract was washed with water, with 1 N sodium hydroxide, then again with water until neutrality, and finally with a saturated sodium chloride solution. The extract was dried, the solvent evaporated off and 220 g of an oil were obtained. The oil solidified on standing and the solid 1-(2',4'-dichlorophenyl)-2-chloro-ethanol melted at 48-51°C.1-(2',4'-Dichlorophenyl)-2-(N-imidazolyl)ethanol:30 g of sodium were added to a solution of 88.5 g of imidazole in 600 ml of methanol; the solvent was then evaporated off. The residue was dissolved in 300 ml of dimethylformamide and heated to 115-120°C. To the solution so obtained was added, dropwise and under stirring, a solution of 225 g of 1- (2',4'-dichlorophenyl)-2-chloroethanol in 400 ml of dimethylformamide. The mixture was heated to 115-120°C and maintained at that temperature for 20 min and, after subsequent cooling to 40°C, 2500 ml of iced water were added under vigorous stirring. The product precipitated under stirring over a period of about two hours, the upper liquid was then decanted off, a further 2500 ml of water were added and, after standing, the whole was filtered. The precipitate thus obtained was dried and crystallized from toluene. 170 g of the 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)ethanol, melting at 134-135°C, was obtained.METHOD 1:A solution of 2.57 g of 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)ethanol in 10 ml of hexamethylphosphoramide was dropped at 25°C into a suspension of 0.52 g of sodium hydride (50% in oil) in 5 ml of hexamethylphosphoramide. When hydrogen emission was over, the salification was completed by heating for 1 hour at 50°C. After cooling to 25°C, 2.58 g of 1-chloromethyl-4- phenylthiobenzene were added. The temperature was raised to 50°C and maintained at that temperature for 12 hours. At the end of the reaction, the mixture was poured into 200 ml of water, the product was extracted with diethyl ether, the solvent was evaporated off and the residue was purified twice on a silica gel column, using ethyl acetate as eluant and testing the various fractions by TLC. The solvent was evaporated off the middle fractions to give 2.4 g of the 1-[2,4-dichloro-beta-[[p-(phenylthio)benzyl]oxy] phenethyl]imidazole as a yellowish oil, showing a single spot on TLC.METHOD 2:0.66 g of sodium hydride (50% in oil) were added at 20-30°C and under nitrogen atmosphere to 3.86 g of 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl) ethanol in 15 ml of dimethylsulphoxide (dried on calcium hydride). The mixture was heated under stirring at 50-60°C until gas emission was over. After cooling to 20-25°C, 0.5 g of potassium iodide were added and slowly a solution of 3.51 g of 1-chloromethyl-4-phenylthiobenzene in 4 ml of dimethylsulphoxide was dropped in. The mixture was stirred at 20-25°C until addition of the 1-chloromethyl-4-phenylthiobenzene was over. The mixture was then poured into 150 ml of water and extracted with diethyl ether. To the etheric solution, after drying on anhydrous sodium sulphate, was added excess 4 N nitric acid solution in diethyl ether: the desired product precipitated as nitrate, an oil which solidified on standing. After standing for 20 hours, the etheric liquid was decanted off and the residue was crystallized from ethanol. The nitrate thus obtained, not completely pure, was dissolved in water and excess sodium carbonate was added in order to liberate the base which was then extracted with ethyl acetate. The base, obtained by filtration, was purified on a silica gel column using ethyl acetate as eluant. The combined fractions containing the desired product were evaporated to dryness. The residue was dissolved in diethyl ether, again transformed into the nitrate and crystallized from ethanol. Yield: 3.1 g of a white crystalline powder, melting at 136°C; λmax 252 nm (methanol).

Brand name


Therapeutic Function


73151-29-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (F1008)  Fenticonazole Nitrate  >97.0%(HPLC) 73151-29-8 200mg 960.00CNY Detail
Sigma-Aldrich (F0060000)  Fenticonazole nitrate  European Pharmacopoeia (EP) Reference Standard 73151-29-8 F0060000 1,880.19CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name fenticonazole nitrate

1.2 Other means of identification

Product number -
Other names Falvin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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