73172-57-3

Upstream product

• 73172-50-6 2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-5-methyl-hex-4-en-1-one 
• 870-63-3 prenyl bromide 
• 125700-07-4 (4-Methoxy-benzoylamino)-phenyl-acetic acid methyl ester 
• 119-52-8 4,4'-dimethoxybenzoin 
• 503-60-6 3,3-dimethyl-allyl chloride 
• 78-84-2 isobutyraldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 201230-82-2 carbon monoxide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Relevant academic research and scientific papers

Zirconocene-Mediated Carbonylative Coupling of Grignard Reagents

Organozirconocenes are versatile synthetic intermediates that can undergo carbonylation to yield acyl anion equivalents. Zirconocene hydrochloride ([Cp2ZrHCl]) is often the reagent of choice for accessing these intermediates but generates organozirconocenes only from alkenes and alkynes. This requirement eliminates a broad range of substrates. For example, organozirconocenes in which the zirconium center is bonded to an aromatic ring, a benzylic group, or an alkyl group that possesses a tertiary or quaternary carbon atom α to the carbon–zirconium bond can not be formed in this way. To provide more generalized access to acyl zirconium reagents, we explored the transmetalation of Grignard reagents with zirconocene dichloride under a CO atmosphere. This protocol generates acyl zirconium(IV) complexes that are inaccessible with the Schwartz reagent, including those derived from secondary and tertiary alkyl and aryl Grignard reagents.

Palladium catalyzed coupling reaction of acylchromate complexes and allylic bromides

A cross-coupling reaction between acylchromate complexes and allylic bromides takes place under CO atmosphere in the presence of a catalytic amount of Pd(PPh3)4 to afford the corresponding allylic ketones in good yield. The same reaction also proceeds by adding RNC under argon atmosphere in place of CO atmosphere. Thus, the acylchromate complex works as a good acyl donor for Pd catalyzed acylation reaction.

Preparation of styryl-cyclopropane-carboxylic acid esters and intermediate therefor

A process for the preparation of a styrylcyclopropane-1-carboxylic acid ester of the formula STR1 in which R is C1-4 -alkyl or an alcohol radical customary in pyrethroids, R1 is alkoxy or alkylthio, either of which may be optionally