73177-32-9Relevant articles and documents
Preparation method of indole compound
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Paragraph 0058-0059, (2020/12/29)
The invention discloses a preparation method of a novel efficient indole compound, which comprises the following steps: by using o-nitroalkylbenzene containing various substituents as a raw material,controlling the reaction temperature to be 70-160 DEG C in an organic solution under the protection of inert gas and the participation of inorganic base, thereby obtaining the indole compound; preparing the novel indole compound containing various substituent groups through a hydrocarbon activation reaction catalyzed by a metal rhodium catalyst. The synthetic method is not reported in literature,the raw materials are easy to synthesize, no reducing agent needs to be added additionally, the method is simple in step, the indole compound containing various substituent groups does not need to beconstructed in one step through a nitroso intermediate, and the yield is high; The method is simple in unit operation, low in equipment requirement and suitable for rapidly synthesizing the indole compounds containing various substituent groups.
Indole Synthesis via SRN1 Reactions
Bard, Raymond R.,Bunnett, Joseph F.
, p. 1546 - 1547 (2007/10/02)
o-Haloanilines react with ketone enolate ions in ammonia under irradiation to form indoles in good yields.
