731815-60-4Relevant academic research and scientific papers
High throughput synthesis of extended pyrazolo[3,4-d]dihydropyrimidines
Ryabukhin, Sergey V.,Granat, Dmitry S.,Plaskon, Andrey S.,Shivanyuk, Alexander N.,Tolmachev, Andrey A.,Volovenko, Yulian M.
, p. 465 - 470 (2012/11/07)
Thirteen 5-hetarylaminopyrazoles were synthesized in 62-93% yield through the arylation of 1-isopropyl- and 1-phenyl-5-aminopyrazoles with electrophilic hetarylhalides under optimized conditions. Condensation of 5- hetarylaminopyrazoles with carbonyl compounds facilitated by AcOH or Me 3SiCl furnished 23 pyrazolo[3,4-d]dihydropyrimidines in 69-86% yield. The target compounds were isolated through simple crystallization. The scope and limitation of the method are discussed.
