731823-46-4Relevant academic research and scientific papers
Dynamic kinetic resolution: An efficient route to anti α-amino- β-hydroxy esters via Ru-SYNPHOS catalyzed hydrogenation
Mordant, Celine,Duenkelmann, Pascal,Ratovelomanana-Vidal, Virginie,Genet, Jean-Pierre
, p. 1296 - 1297 (2007/10/03)
The Ru(II)-catalyzed hydrogenation of α-amino-β-keto esters as their hydrochloride salts affords preparation of the corresponding anti α-amino-β-hydroxy esters under mild conditions with high diastereoselectivities and enantioselectivities via dynamic kinetic resolution.
A versatile route to syn- and anti-α-amino β-hydroxy esters from β-keto esters by dynamic kinetic resolution with Ru-SYNPHOS catalyst
Mordant, Celine,Duenkelmann, Pascal,Ratovelomanana-Vidal, Virginie,Genet, Jean-Pierre
, p. 3017 - 3026 (2007/10/03)
A general and practical synthesis of both syn- and anti-α-amino β-hydroxy esters with high levels of selectivity by the use of Ru-SYNPHOS catalysts is reported. The key transformations include asymmetric hydrogenations of α-N-substituted β-keto esters pro
