731859-46-4

Upstream product

• 105499-11-4 2-(Boc-amino)propionaldehyde 
• 163594-14-7 (2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester 
• 79069-50-4 Boc-Ala-H 

Downstream Products

• 731859-55-5 2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrole-4-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of fused heteroarylprolines and pyrrolopyrroles

Fused heteroarylprolines were prepared starting from 4-oxo-N-(PhF)proline benzyl ester (6, PhF = 9-(9-phenylfluorenyl) following two approaches. First, allylation of oxoproline 6 followed by Wacker oxidation gave 1,4-dione 8 that was selectively converted

Large structural modification with conserved conformation: Analysis of Δ3-fused aryl prolines in model β-turns

For the first time, the influence of a fused Δ3-arylproline on peptide conformation has been studied by the synthesis and comparison of the conformations of peptides containing proline and pyrrolo-proline, 3 (PyPro). Pyrrolo-proline was demonst