73198-03-5 Usage
Chemical structure
A complex structure with a beta-carboline derivative and a carboxylic acid group.
Molecular weight
238.30 g/mol
Appearance
Unknown, but likely a solid due to the presence of a carboxylic acid group.
Solubility
Likely soluble in polar solvents such as water and methanol, due to the presence of a carboxylic acid group.
Biological activities
Studied for its effects on the central nervous system and potential role in neurodegenerative diseases.
Medicinal chemistry
Potential applications in the development of new drugs targeting neurological disorders.
Research status
Further research is needed to fully understand the pharmacological properties and potential therapeutic uses of this compound.
Stability
Unknown, but may be sensitive to heat, light, and moisture due to the presence of a carboxylic acid group.
Reactivity
Likely to react with bases, as it contains a carboxylic acid group, which can form salts with bases.
Check Digit Verification of cas no
The CAS Registry Mumber 73198-03-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,1,9 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 73198-03:
(7*7)+(6*3)+(5*1)+(4*9)+(3*8)+(2*0)+(1*3)=135
135 % 10 = 5
So 73198-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2O2/c1-14(2)12-9(7-11(16-14)13(17)18)8-5-3-4-6-10(8)15-12/h3-6,11,15-16H,7H2,1-2H3,(H,17,18)
73198-03-5Relevant articles and documents
Discovery of pyridoindole derivatives as potential inhibitors for phosphodiesterase 5A: in silico and in?vivo studies
Mali, Dipak P.,Gaikwad, Dinanath T.,Bhatia, Manish S.,Bhatia, Neela M.
, (2021/05/27)
The aim of this work was to synthesise derivatives from identified plant based pyridoindole lead scaffold, and to assess phosphodiesterase 5A inhibitory potential by in silico and in?vivo. Pyridoindole derivatives were synthesised by using six-stage reactor. In silico screening was carried out by grip-based docking methodology. In step-I, tryptophan as a starting material was reacted with different aldehydes and ketones to obtain 11 molecules. In step-II, obtained molecules were reacted with ethanol and benzyl alcohols to obtain D1 to D22 derivatives. In silico investigation resulted in best three molecules D12, D4 and D8 with promising BE score. Oral acute toxicity study of selected molecules resulted in LD50 value 500 mg/kg in rats. The result of in?vivo antihypertensive study shown that molecule D12 was found to be the best antihypertensive lead molecule. This study could be a best platform to tailor novel biomolecules for inhibiting phosphodiesterase 5A enzyme in hypertension management.
