732-55-8

Basic information

• Product Name: Methanone, (4-hydroxyphenyl)[3-(trifluoromethyl)phenyl]-
• CAS NO: 732-55-8
• Molecular Formula: C14H9F3O2
• Molecular Weight: 266.219
• Mol File: 732-55-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, (4-hydroxyphenyl)[3-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-hydroxyphenyl)[3-(trifluoromethyl)phenyl]-(732-55-8)
• EPA Substance Registry System: Methanone, (4-hydroxyphenyl)[3-(trifluoromethyl)phenyl]-(732-55-8)

Safety Data

• Hazardous Substances Data: 732-55-8(Hazardous Substances Data)

Upstream product

• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 536-45-8 sodium anisate 
• 100-66-3 methoxybenzene 
• 845-05-6 3-Trifluoromethylphenyl 4-methoxyphenyl ketone 

Downstream Products

• 67244-23-9 α-ethyl-α-(3-trifluoromethylphenyl)-4-hydroxy-benzylalcohol 

Relevant articles and documents

Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase

We discovered a new series of 4-phenoxyquinoline derivatives as potent and selective inhibitors of the platelet-derived growth factor receptor (PDGFr) tyrosine kinase. We researched the highly potent and selective inhibitors on the basis of both PDGFr and epidermal growth factor receptor (EGFr) inhibitory activity. First, we found a compound, Ki6783 (1), which inhibited PDGFr autophosphorylation at 0.13 μM, but it did not inhibit EGFr autophosphorylation at 100 μM. After extensive explorations, we found the two desired compounds, Ki6896 (2) and Ki6945 (3), which are substituted by benzoyl and benzamide at the 4-position of the phenoxy group on 4-phenoxyquinoline, respectively. These inhibitory activities were 0.31 and 0.050 μM, respectively, but neither of them inhibited EGFr autophosphorylation at 100 μM. We further investigated the profile of both compounds toward various tyrosine and serine/threonine kinases. The three compounds specifically inhibited PDGFr rather than the other kinases.

Phenylmethylphenoxy propionic acid esters

Compounds of the formula STR1 in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X4 and X5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X0 is O or OCH2 CH2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.