73216-87-2Relevant articles and documents
Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors
Bellomo, Ana,Celebi-Olcum, Nihan,Bu, Xiaodong,Rivera, Nelo,Ruck, Rebecca T.,Welch, Christopher J.,Houk, Kendall N.,Dreher, Spencer D.
, p. 6912 - 6915 (2012/10/08)
A microscale chemistry improvement engine: A pre-dosed microscale high-throughput experimentation additives platform enables rapid, serendipitous reaction improvement. This platform allowed one chemist to set up 475 experiments and analyze the results using MISER chromatography in a single day, thus resulting in two high-quality catalytic systems for the construction of the title compound 1. Support for a single-electron transfer mechanism was obtained. Copyright