73220-38-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-6-chlorochromone is used as a building block for the synthesis of other pharmaceutical compounds due to its unique molecular structure and reactivity.
Used in Medicinal Applications:
3-Bromo-6-chlorochromone is used as an anti-inflammatory agent for its potential therapeutic uses in reducing inflammation.
Used in Anticancer Applications:
3-Bromo-6-chlorochromone is used as an anti-cancer agent, showing potential in various research studies for its ability to target and inhibit cancer cells.
Used in Anti-microbial Applications:
3-Bromo-6-chlorochromone is used as an anti-microbial agent for its potential to combat and inhibit the growth of microorganisms.
Used in Drug Development:
3-Bromo-6-chlorochromone is used in the development of new drug candidates for its potential therapeutic uses and as a valuable chemical in medicinal applications.

Upstream product

• 73220-32-3 C₁₁H₁₂ClNO₂ 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 6342-64-9 2-methoxy-5-chloroacetophenone 
• 55877-79-7 2-methoxy-5-chlorobenzonitrile 

Downstream Products

• 42972-67-8 6-chloro-3-phenyl-4H-chromen-4-one 
• 145013-56-5 6-chloro-3-(4-chlorophenyl)-4H-chromen-4-one 
• 130252-74-3 6-chloro-3-(4-methoxyphenyl)-4H-chromene-4-one 
• 131168-61-1 6-chloro-3-(p-tolyl)-4H-chromen-4-one 
• 1429426-11-8 2-(5-chloro-2-hydroxybenzoyl)-4H-furo[3,2-c]chromen-4-one 

Relevant academic research and scientific papers

Synthesis of 3-halochromones with simple KX halogen sources enabled by: In situ halide oxidation

On the basis of a designated in situ oxidation tactic, the synthesis of 3-halochromones has been realized for the first time by using simple KX (X = Br, I) salts as halogen sources. Instead of the free radical process, the control experiments indicate that the reported reactions proceed through a halogenium intermediate. Compared to the known synthetic methods relying on molecular halogen, haloid acid or N-halosuccinimide as the halogen source, the present method is attractive due to its higher atom economy and being more friendly to the operator, thus providing a practical complimentary approach to the preparation of useful halochromone compounds.

Chromenones as potent bradykinin B1 antagonists

A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.