732211-08-4

Upstream product

• 100-51-6 benzyl alcohol 
• 85003-76-5 N-t-Butoxycarbonyl-S-(2-carbobenzyloxyaminoethyl)-L-cysteine 
• 1198185-64-6 Benzyl (R)-3-(2-benzyloxycarbonylaminoethylsulfanyl)-2-tert-butoxycarbonylaminopropionate 

Downstream Products

• 1198185-68-0 Benzyl (R)-3-(2-benzyloxycarbonylaminoethylsulfanyl)-2-[3-((9S,12R)-9-isopropyl-11-oxo-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1⁽¹⁷⁾,14⁽¹⁸⁾,15-trien-12-yl)ureido]propionate 
• 1198185-70-4 benzyl (R)-3-(2-benzyloxycarbonylaminoethanesulfonyl)-2-[3-((9S,12R)-9-isopropyl-11-oxo-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1⁽¹⁷⁾,14⁽¹⁸⁾,15-trien-12-yl)ureido]propionate 

Relevant academic research and scientific papers

MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIa

The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.