732247-32-4Relevant academic research and scientific papers
Double stereodifferentiating aldol reactions based on chiral ketones derived from lactic acid: Synthesis of C1-C6 fragment of erythronolides
Solsona, Joan G.,Nebot, Joaquim,Romea, Pedro,Urpí, Fèlix
, p. 2127 - 2130 (2007/10/03)
Highly stereoselective titanium-mediated aldol additions of ethyl ketones derived from lactic acid to α-methyl-β-OTBDPS chiral aldehydes are documented. One of these double stereodifferentiating processes represents the key step of a straightforward and e
Stereoselective titanium-mediated syn-aldol reaction from a lactate-derived chiral ethyl ketone
Solsona, Joan G.,Romea, Pedro,Urpí, Fèlix
, p. 5379 - 5382 (2007/10/03)
Stereoselectivity of the titanium-mediated aldol process based on (S)-2-benzyloxy-3-pentanone, 1, is dramatically modified by the presence of a Lewis acid. Among the Lewis acids surveyed, TiCl4 has given access to the corresponding 2,4-anti-4,5-syn aldol adducts with the highest diastereomeric ratios. The excellent stereocontrol exerted by the aforementioned ketone has been demonstrated in double asymmetric reactions involving chiral α-methyl-β-OTBDPS aldehydes.
