132489-33-9Relevant articles and documents
Deracemization of acyclic α-hydroxy ketone derivatives by dynamic resolution using an optically active host compound
Matsumoto, Kazutsugu,Otsuka, Keiko,Okamoto, Tomomi,Mogi, Hideto
, p. 729 - 732 (2007)
The dynamic resolution of racemic acyclic α-hydroxy ketone derivatives is accomplished using an optically active host compound, TADDOL, under basic conditions to give the corresponding optically active ketones. Georg Thieme Verlag Stuttgart.
Toward Chromanes by de Novo Construction of the Benzene Ring
Geist, Egor,Berneaud-K?tz, Helge,Baikstis, Tomas,Dr?ger, Gerald,Kirschning, Andreas
supporting information, p. 8930 - 8933 (2019/11/14)
The work describes three principal Diels-Alder cycloaddition approaches toward chromanes that are designed for the de novo construction of the benzene ring. This study specifically focuses on the potential exploitation in the total synthesis of chromane-bearing natural products such as cebulactam A.
Preparation method of high-purity posaconazole
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Paragraph 0043; 0044; 0049; 0050; 0072; 0074; 0079; 0080, (2019/06/27)
The invention discloses a preparation method of posaconazole, comprising: subjecting BP004b04 and oxalic acid to salt forming to obtain POE; subjecting POE and di-tert-butyl decarbonate to reaction inthe presence of a base to obtain POP, and recrystallizing POP; subjecting POP and POK o reaction in the presence of a base to obtain POR, and removing tert-butyl carbonate protecting group from POR to obtain POS; subjecting the POS to ring closing to obtain POB; subjecting the POB and POA to reaction to obtain posaconazole. Posaconazole prepared via the preparation method has the content of diastereoisomers being /=0.01%, and the overall route has high total yield.