732310-19-9Relevant academic research and scientific papers
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation
Sun, Qi,Burke, Jason P.,Phan, Jason,Burns, Michael C.,Olejniczak, Edward T.,Waterson, Alex G.,Lee, Taekyu,Rossanese, Olivia W.,Fesik, Stephen W.
, p. 6140 - 6143 (2012)
Looking for fragments: A fragment-based screen using NMR spectroscopy was applied to discover ligands that bind to the GTPase K-Ras and modulate the activity of the nucleotide exchange factor Sos. Structural data on how these fragment-derived hits bind to the guanosine diphosphate-K-Ras complex (see picture) provides a starting point for the future discovery of drugs that target K-Ras activation and signaling. Copyright
Sulfonamide urease inhibiting agent and preparation method and application thereof
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Paragraph 0037-0039; 0045; 0046, (2019/01/14)
Benzene sulfonamide compounds have a structural formula as shown in the specification, have great inhibiting effects on urease and can be used for preparation of medicines for treating gastritis, gastric ulcer, lithangiuria and the like. The invention fur
