7324-89-2

Upstream product

• 64-17-5 ethanol 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 107-91-5 cyanoacetic acid amide 
• 6013-05-4 2-cyano-3t-(2,4-dichloro-phenyl)-acrylic acid 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 103754-45-6 2,4-Dichlorophenyl-succinic acid 
• 1204165-02-5 diethyl 6-amino-8-(2,4-dichlorophenyl)-5,7-dicyano-3,4,7,8-tetrahydroisoquinoline-2,7(1H)-dicarboxylate 
• 1233207-73-2 3-(2-chloro-6-fluoro-benzyl)-5-(2,4-dichloro-benzylidene)-thiazolidine-2,4-dione 
• 1385784-15-5 ethyl-2-amino-5-cyano-1-[1-(2,5-dimethoxyphenyl)ethylideneamino]-6-oxo-4-(2,4-dichlorophenyl)-1,6-dihydropyridine-3-carboxylate 
• 1266549-99-8 ethyl 2-amino-4-(2,4-dichlorophenyl)-5-oxo-4,5,6,7-tetrahydrocyclopenta[b]pyran-3-carboxylate 
• 102653-71-4 3-(2,4-dichloro-phenyl)-pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation

Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of

Novel synthesis of 3-cyano-2-pyridones derivatives catalyzed by Au–Co/TiO2

Abstract: The current work described a new and highly selective method for the synthesis of substituted 3-cyano-2-pyridones scaffolds using gold-cobalt supported on TiO2 as a robust and recyclable catalyst. The products were successfully obtained by one-pot, multicomponent manner. This procedure generated the desired products 2-pyridones derivatives in good yields, from simple and available starting materials using heterogeneous and reusable catalyst. The diversity of 3-cyano-2-pyridones derivatives was prepared and characterized by IR, 1H and 13C NMR data and confirmed by element analysis data. Graphic abstract: [Figure not available: see fulltext.].

DABCO-catalyzed Knoevenagel condensation of aldehydes with ethyl cyanoacetate using hydroxy ionic liquid as a promoter

N-(2-Hydroxy-ethyl)-pyridinium chloride ([HyEtPy]Cl) was synthesized and explored as a novel promoter for 1,4-diazabicyclo [2.2.2] octane (DABCO)-catalyzed Knoevenagel condensation reactions, which showed better catalytic activity compared to other ionic liquid (IL) that had no hydroxyl group attached to the IL scaffold. The effect of hydrogen bond formation between the hydroxyl group of [HyEtPy]Cl and the carbonyl group of aldehyde played an important role in the Knoevenagel condensation reaction. In the [HyEtPy]Cl-H2O-DABCO composite system, Knoevenagel condensation reactions proceeded smoothly and cleanly, and the corresponding Knoevenagel condensation products were obtained in good to excellent yields in all cases examined. This protocol provides a versatile solvent-catalyst system, which has notable advantages such as being eco-friendly, ease of work-up and convenient reuse of the ionic liquid.

Asymmetric Reaction of p-Quinone Diimide: Organocatalyzed Michael Addition of α-Cyanoacetates

Hitherto unknown catalytic enantioselective transformation of p-quinone diimides is achieved using chiral bifunctional organic molecules. Bifunctional thiourea compounds catalyze the Michael addition of cyanoacetates with excellent yields and enantioselec

Direct Three-Component Synthesis of α-Cyano Acrylates Involving Cascade Knoevenagel Reaction and Esterification

A direct three-component approach has been developed for the synthesis of α-cyano acrylates starting from aldehydes, alcohols and α-cyano acetamide by employing cyanuric chloride as an organocatalyst. A class of structurally diverse α-cyano acrylates have been provided with good to excellent yields via the cascade transformation of Knoevenagel condensation and amide esterification.

Efficient tandem synthesis of a variety of pyran-annulated heterocycles, 3,4-disubstituted isoxazol-5(4H)-ones, and α,β-unsaturated nitriles catalyzed by potassium hydrogen phthalate in water

A variety of 4H-chromenes, benzochromenes, 4,5-dihydropyrano[3,2-c]chromenes, 4H-pyran-3-carboxylates, and 3,4-disubstituted isoxazol-5(4H)-ones have been synthesized in high yields by using potassium hydrogen phthalate (KHP) as an inexpensive, commercially available catalyst. It was found that the three-component tandem reaction enabled synthesis of pyran-annulated heterocycles in water at 50 °C. 3,4-Disubstituted isoxazol-5(4H)-ones were synthesized by use of 10 mol% KHP in water at room temperature. Also, treatment of methylene-containing compounds (malononitrile or ethyl cyanoacetate) with aromatic aldehydes in the presence of 5 mol% KHP resulted in α,β-unsaturated nitriles. The procedure is an easily performed, straightforward method for synthesis of a variety of pyran-annulated compounds, isoxazol-5(4H)-one-containing heterocycles, and Knoevenagel adducts. The reaction is safe, uses mild conditions, and is environmentally benign. Other notable advantages are reuse of the catalyst, no use of hazardous organic solvents, and ease of work-up.

Synthesis, characterization and heterogeneous catalytic activity of diamine-modified silica-coated magnetite-polyoxometalate nanoparticles as a novel magnetically-recoverable nanocatalyst

Magnetite-polyoxometalate hybrid nanomaterials, Fe3O 4@SiO2@NH-NH2-PW, was prepared by grafting of H3PW12O40 on the diamine-functionalized Fe 3O4 magnetite

Kinetic insights of DNA/RNA segment salts catalyzed knoevenagel condensation reaction

In this work, we demonstrated that (i) salts of RNA/DNA segments were capable of catalyzing Knoevenagel condensation at physiological pH 7.0 with efficiency comparable to one of the best enzymes, porcine pancreatic lipase (PPL); and (ii) a broad scope of

One-by-one hydrogenation, cross-coupling reaction, and Knoevenagel condensations catalyzed by PdCl2 and the downstream palladium residue

A novel catalyst-economic strategy with a recovered palladium catalyst was successfully applied for multi-task and maximum reuse in different types of one-by-one downstream reactions, from catalytic hydrogenation to Suzuki and Sonogashira-type cross-coupling reactions, Knoevenagel condensations, and trans-Knoevenagel-like condensations.

Sodium benzoate as a green, efficient, and recyclable catalyst for knoevenagel condensation

Sodium benzoate was utilized as a novel efficient and green catalyst for the Knoevenagel condensation of aldehydes with active methylene compounds such as ethyl cyanoacetate and malononitrile to afford substituted olefins through the conventional stirring