ETHYL 2-CYANO-3-(2,4-DICHLOROPHENYL)ACRYLATE

Base Information

• Chemical Name: ETHYL 2-CYANO-3-(2,4-DICHLOROPHENYL)ACRYLATE
• CAS No.: 7324-89-2
• Molecular Formula: C₁₂H₉Cl₂NO₂
• Molecular Weight: 270.115
• Hs Code.: 2926909090
• Mol file: 7324-89-2.mol

Synonyms:ETHYL 2-CYANO-3-(2,4-DICHLOROPHENYL)ACRYLATE;AKOS USSH-4110511;RARECHEM AL BR 0019;ethyl (2E)-2-cyano-3-(2,4-dichlorophenyl)acrylate

Chemical Property of ETHYL 2-CYANO-3-(2,4-DICHLOROPHENYL)ACRYLATE

Chemical Property:

• Melting Point: 82-84°
• PSA: 50.09000
• LogP: 3.46348

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-cyano-3-(2,4-dichlorophenyl)acrylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-CYANO-3-(2,4-DICHLOROPHENYL)ACRYLATE

There total 7 articles about ETHYL 2-CYANO-3-(2,4-DICHLOROPHENYL)ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-dichlorobenzaldeyhde (874-42-0) + ethyl 2-cyanoacetate (105-56-6) → ethyl (E)-2-cyano-3-(2,4-dichlorophenyl)-2-propenoate (7324-89-2,24393-45-1)

Guidance literature:

With sodium benzoate; at 20 ℃; for 1.8h; Sonication; neat (no solvent);

DOI:10.1080/00397911.2011.574245

Reference yield: 97.0%

2,4-dichlorobenzaldeyhde (874-42-0) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-cyano-3-(2,4-dichlorophenyl)acrylate (24393-45-1,7324-89-2)

Guidance literature:

With recovered palladium catalyst; In ethanol; at 20 ℃; for 18h; Green chemistry;

DOI:10.1039/c3gc40991k

Reference yield: 82.0%

ethanol (64-17-5) + 2,4-dichlorobenzaldeyhde (874-42-0) + cyanoacetic acid amide (107-91-5) → ethyl 2-cyano-3-(2,4-dichlorophenyl)acrylate (24393-45-1,7324-89-2)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; In neat (no solvent); at 80 ℃; for 12h;

DOI:10.1002/cjoc.201500420

upstream raw materials:

2,4-dichlorobenzaldeyhde

ethyl 2-cyanoacetate

ethanol

cyanoacetic acid amide

Downstream raw materials:

ethyl 2-amino-4-(2,4-dichlorophenyl)-5-oxo-4,5,6,7-tetrahydrocyclopenta[b]pyran-3-carboxylate

Refernces

• 1、 Mehiaoui, Nawel,Kibou, Zahira,Berrichi, Amina,Bachir, Redouane,Choukchou-Braham, Noureddine. "Novel synthesis of 3-cyano-2-pyridones derivatives catalyzed by Au–Co/TiO2". . p. 5263 - 5280. Retrieved 2020/09/21.
• 2、 Reddy, Sivakumar N.,Reddy, Venkatram R.,Dinda, Shrabani,Nanubolu, Jagadeesh Babu,Chandra, Rajesh. "Asymmetric Reaction of p-Quinone Diimide: Organocatalyzed Michael Addition of α-Cyanoacetates". supporting information. p. 2572 - 2575. Retrieved 2018/05/17.