73240-15-0Relevant academic research and scientific papers
Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ
Desieno, Matthew A.,Van Der Donk, Wilfred A.,Zhao, Huimin
, p. 10025 - 10027 (2011)
The Fe(ii) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials. The Royal Society of Chemistry 2011.
