73249-95-3Relevant academic research and scientific papers
Inorganic alkali catalytic 1, 5 - ketonic ester apperception compound synthesis method
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Paragraph 0060-0062, (2017/10/11)
The invention discloses a synthesis method for a 1,5-ketonic ester compound under catalyzing of inorganic base. The synthesis method comprises the following steps: taking a compound of the general formula I as a raw material, taking inorganic base as a ca
Sequential Michael addition/retro-Claisen condensation of aromatic β-diketones with α,β-unsaturated esters: An approach to obtain 1,5-ketoesters
Cai, Gui-Xin,Wen, Jing,Lai, Ting-Ting,Xie, Dan,Zhou, Cheng-He
supporting information, p. 2390 - 2394 (2016/03/01)
A K2CO3-catalyzed one-pot protocol involving sequential C-C bond formation and cleavage of aromatic β-diketones with α,β-unsaturated esters is developed to obtain 1,5-ketoesters. The sequential reaction via Michael addition and retro-Claisen condensation proceeds smoothly under mild conditions in up to 98% isolated yield. The mechanism study disclosed that the cascade process involved C-C bond cleavage of aromatic β-diketone as a phenacyl donor under alcoholic alkalescent conditions.
Indium-trichloride catalyzed Michael reaction of silyl enol ethers with α,β-unsaturated carbonyl compounds under neat condition
Loh, Teck-Peng,Wei, Lin-Li
, p. 7615 - 7624 (2007/10/03)
In the presence of a catalytic amount of indium (III) trichloride (InCl3) (20 mol%), ketene silyl enol ethers react quickly with α, β- unsaturated ketones and esters to afford the corresponding Michael adducts in moderate to good yields. Indium(III) trichloride can be recovered and reused without decrease in yields.
α,β-Unsaturated Orthoesters as Michael Acceptors. The Trityl Salt-Catalyzed Michael Reaction of α,β-Unsaturated Orthoesters with Silyl Enol Ethers
Kobayashi, Shu,Mukaiyama, Teruaki
, p. 1183 - 1186 (2007/10/02)
In the presence of a catalytic amount of trityl salts, α,β-unsaturated orthoesters react with various silyl enol ethers to afford the corresponding Michael adducts in good yields.
ACTIVATION OF SILICON-HYDROGEN, SILICON-OXYGEN, SILICON-NITROGEN BONDS IN HETEROGENEOUS PHASE SOME NEW METHODS IN ORGANIC SYNTHESIS
Corriu, R. J. P.,Perz, R.,Reye, C.
, p. 999 - 1010 (2007/10/02)
Anionic activation of Si-H, Si-O and Si-N bonds by fluoride ions under heterogeneous conditions is reported: Si-H activated by KF or CsF is a powerful and selective reducing reagent; the carbonyl group of aldehydes, ketones or esters can be reduced without reduction of other functional groups (C=C, NO2, Br, amido).Furthermore, selective reductions of aldehydes in the presence of ketones and ketones in the presence of carboxylic esters are also possible.CsF in the presence of Si(OR)4 is found to be very efficient in promoting Michael additions of monoketones andarylacetonitriles on different kinds of Michael acceptors such as α, β unsaturated ketones, esters, nitriles and even amides.This constitutes an extension of Michael reaction since the addition occurs even with crowded ketones.N,N bis(silyl)enamines activated by fluoride ions react with carbonyl compounds and provide an interesting route to 2-aza-1,3 dienes.
EXTENSION DE LA REACTION DE MICHAEL EN PRESENCE CsF/Si(OR)4
Boyer, J.,Corriu, R. J. P.,Perz, R.,Reye, C.
, p. 117 - 122 (2007/10/02)
An extension of the Michael reaction is described.CsF in the presence of Si(OR)4 is found to be very efficient for carrying out Michael additions of monoketones and arylacetonitriles on different kinds of Michael acceptors: α,β unsaturated ketones, esters
CsF-promoted Michael Addition in Heterogeneous Catalysis
Boyer, Jacqueline,Corriu, Robert J. P.,Perz, Robert,Reye, Catherine
, p. 122 - 123 (2007/10/02)
CsF in the presence of Si(OR)4 is found to be an efficient, simple catalyst for the Michael addition of monoketones; yields are satisfactory and side reactions are not observed.
