73252-65-0

Basic information

• Product Name: methyl 2-formyl-4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2'-carboxylate
• Synonyms: methyl 2-formyl-4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2'-carboxylate
• CAS NO: 73252-65-0
• Molecular Weight: 374.347
• Mol File: 73252-65-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-formyl-4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-formyl-4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2'-carboxylate(73252-65-0)
• EPA Substance Registry System: methyl 2-formyl-4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2'-carboxylate(73252-65-0)

Safety Data

• Hazardous Substances Data: 73252-65-0(Hazardous Substances Data)

Upstream product

• 1968-71-4 methyl 2-bromo-3,4,5-trimethoxybenzoate 
• 94838-88-7 2-formyl-4,5-(methylenedioxy)benzeneboronic acid 
• 214260-74-9 methyl 2-iodo-3,4,5-tri-methoxybenzoate 
• 58343-51-4 2-Br-4,5-(OCH₂O)C₆H₂C(H)=N(Cy) 

Relevant articles and documents

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents

Twenty-six unsymmetrical biphenyls were synthesized and evaluated for cytotoxic activity against DU145, A549, KB and KB-Vin tumor cell lines. Three compounds 27, 35 and 40 showed very potent activity against the HTCL panel with an IC50 value range of 0.04-3.23 μM. In addition, fourteen active compounds were all more potent against the drug-resistant KB-Vin cell line than the parental KB cell line. Preliminary SAR analysis indicated that two bulky substituents on the 2,2′-positions of unsymmetrical biphenyl skeleton are necessary and crucial for in vitro anticancer activity, thus providing a good starting point to develop unsymmetrical biphenyls as novel anticancer agents.