94838-88-7

Basic information

• Product Name: 2-FORMYL-4,5-METHYLENEDIOXYPHENYLBORONIC ACID
• Synonyms: (2-FORMYL-4,5-METHYLENEDIOXY)BENZENEBORONIC ACID;2-FORMYL-4,5-METHYLENEDIOXYPHENYLBORONIC ACID;6-FORMYLBENZO[D][1,3]DIOXOL-5-YLBORONIC ACID;(6-formyl-1,3-benzodioxol-5-yl)boronic acid
• CAS NO: 94838-88-7
• Molecular Formula: C₈H₇BO₅
• Molecular Weight: 193.95
• Product Categories: blocks;BoronicAcids;Aldehyde;Aryl;Organoborons;Aldehydes;Aryl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Building Blocks;C8;Carbonyl Compounds;Chemical Synthesis;Monosubstituted Aryl Boronic Acids;Organic Building Blocks;Organometallic Reagents
• Mol File: 94838-88-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 231-233
• Boiling Point: 434.3 °C at 760 mmHg
• Flash Point: 216.5 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 2.59E-08mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• PKA: 8.13±0.20(Predicted)
• CAS DataBase Reference: 2-FORMYL-4,5-METHYLENEDIOXYPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYL-4,5-METHYLENEDIOXYPHENYLBORONIC ACID(94838-88-7)
• EPA Substance Registry System: 2-FORMYL-4,5-METHYLENEDIOXYPHENYLBORONIC ACID(94838-88-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• Hazardous Substances Data: 94838-88-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 94838-88-7 differently. You can refer to the following data:
1. Reactant for:? ;Enantioselective preparation of indenamines by cationic palladium complex-catalyzed tandem annulation with alkynes1? ;Stereoselective preparation of indenol derivatives via cationic palladium complex-catalyzed diastereoselective tandem annulation2? ;Synthesis of oxazoline-substituted potassium organotrifluoroborates3? ;Preparation of aristolactam analogs as an antitumor agent4? ;Suzuki-Miyaura coupling reactions5? ;Suzuki and Negishi cross-coupling reactions6
2. Reactant for:Enantioselective preparation of indenamines by cationic palladium complex-catalyzed tandem annulation with alkynesStereoselective preparation of indenol derivatives via cationic palladium complex-catalyzed diastereoselective tandem annulationSynthesis of oxazoline-substituted potassium organotrifluoroboratesPreparation of aristolactam analogs as an antitumor agentSuzuki-Miyaura coupling reactionsSuzuki and Negishi cross-coupling reactions

InChI:InChI=1/C8H7BO5/c10-3-5-1-7-8(14-4-13-7)2-6(5)9(11)12/h1-3,11-12H,4H2

Upstream product

• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 

Downstream Products

• 258283-81-7 6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde 
• 73252-65-0 methyl 2-formyl-4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2'-carboxylate 
• 61599-76-6 4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2,2'-dicarboxaldehyde 
• 880643-58-3 6-(cyclohex-1-en-1-yl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 42123-15-9 6-<(3,4,5-trimethoxyphenyl)methyl>benzo-1,3-dioxole-5-carboxaldehyde 
• 1589546-26-8 C₃₀H₂₁O₄P 
• 1459238-37-9 6-(2-bromo-4-methoxyphenyl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 1149344-98-8 6-(2-acetyl-5-fluorophenyl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 1149344-88-6 6-(2-acetylphenyl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 258283-80-6 6-[2,3,4-trimethoxy-6-(2-oxo-2,5-dihydro-furan-3-ylmethyl)-phenyl]-benzo[1,3]dioxole-5-carbaldehyde 
• 258283-82-8 6-(6-bromomethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde 

Relevant articles and documents

Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases

The production of β-lactamases represents the main cause of resistance to clinically important β-lactam antibiotics. Boron containing compounds have been demonstrated as promising broad-spectrum β-lactamase inhibitors to combat β-lactam resistance. Here we report a series of 3-aryl substituted benzoxaborole derivatives, which manifested broad-spectrum inhibition to representative serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs). The most potent inhibitor 9f displayed an IC50 value of 86 nM to KPC-2 SBL and micromolar inhibitory activity towards other tested enzymes. Cell-based assays further revealed that 9f was able to significantly reduce the MICs of meropenem in clinically isolated KPC-2-producing bacterial strains and it showed no apparent toxicity in HEK293T cells.