73258-84-1Relevant academic research and scientific papers
Transition metal-free synthesis of primary amides from aldehydes and hydroxylamine hydrochloride
Wang, Wei,Zhao, Xue-Mei,Wang, Jing-Li,Geng, Xin,Gong, Jun-Fang,Hao, Xin-Qi,Song, Mao-Ping
supporting information, p. 3192 - 3194 (2014/05/20)
Primary aromatic amides can be synthesized from aldehydes and hydroxylamine hydrochloride in the presence of Cs2CO3. Various aromatic aldehydes (include some heteroaromatic aldehydes) are able to generate the corresponding aromatic amides in moderate to excellent yields.
Therapeutic substituted indole compounds and compositions thereof
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, (2008/06/13)
The present invention is concerned with compounds of formula (I) STR1 wherein R, R1 and R2 are independently selected from hydrogen and C1-4 alkyl; R3 and R4 are independently selected from hydrogen, C1-6 alkyl (including cycloalkyl) and aryl (wherein the alkyl or aryl group, which latter includes benzyl, is optionally substituted by one or more atoms or groups independently selected from halogen, C1-4 alkyl and aryl), provided R3 benzyl or substituted benzyl when R4 =H; m is an integer of from 0 to 2; n is an integer of from 0 to 3; (W) is a group of formula (i), (ii), (iii), or (iv) STR2 wherein Y is selected from oxygen, methylene and >N--R5, where R5 is hydrogen, C1-4 alkyl, or benzyl, Z and Z' are independently selected from >C=O, >C=S and methylene, and the chiral center * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; X is a group selected from aryl (including heteroaryl) xanthenyl dibenzofuranyl which group is optionally substituted; and salts and solvates thereof, the preparation of these compounds, pharmaceutical formulations containing them and their use in medicine, particularly in the treatment of migraine.
N-[Diaminophosphinyl]arylcarboxamides
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, (2008/06/13)
A series of N-[diaminophosphinyl]arylcarboxamides are useful as inhibitors of the enzyme urease.
