73269-32-6

Usage

Uses

Used in Pharmaceutical Synthesis:
5-(4-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its potential pharmacological and biological activities. The presence of the fluorine atom in its structure may enhance the compound's lipophilicity, metabolic stability, and receptor binding affinity, making it a valuable building block in drug discovery and development.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-(4-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is used as a precursor in the development of novel agrochemicals with improved efficacy and selectivity. Its unique structural features may contribute to the design of new pesticides, herbicides, or insecticides with enhanced performance and reduced environmental impact.
Used in Organic Synthesis:
5-(4-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID serves as a versatile building block in organic synthesis, allowing for the creation of a wide range of chemical compounds with diverse applications. Its carboxylic acid functional group can be readily modified through various chemical reactions, enabling the synthesis of complex organic molecules for use in materials science, catalysis, and other fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-(4-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is utilized as a starting material for the design and synthesis of new bioactive molecules with potential therapeutic applications. Its unique structural features, including the fluorine atom and furan ring, may impart specific biological activities, making it a valuable component in the development of innovative pharmaceutical agents.
Overall, 5-(4-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is a versatile and promising chemical compound with a wide range of applications in various industries, including pharmaceuticals, agrochemicals, organic synthesis, and medicinal chemistry. Its unique structural features and potential biological activities make it an attractive candidate for further research and development.

InChI:InChI=1/C11H7FO3/c12-8-3-1-7(2-4-8)9-5-6-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 88-14-2 2-furanoic acid 
• 371-40-4 4-fluoroaniline 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 1765-93-1 4-fluoroboronic acid 
• 852145-97-2 5-(4-fluorophenyl)furan-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 

Downstream Products

• 500605-04-9 N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-(4-fluorophenyl)-2-furamide Hydrochloride 
• 380889-69-0 C₁₁H₆ClFO₂ 
• 720672-18-4 6-[5-(4-fluorophenyl)furan-2-yl]-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 852145-97-2 5-(4-fluorophenyl)furan-2-carboxylic acid methyl ester 
• 1354698-29-5 N-5-(4'-fluorophenyl)-2-furoyl-1H-1,2,4-triazole 
• 1354698-18-2 N-5-(4'-fluorophenyl)-2-furoyl-1H-pyrazole 
• 1410785-84-0 C₂₀H₁₄ClFN₂O₃ 
• 1120353-33-4 N-(2-chlorobenzoyl)-N′-[5-(4′-fluorophenyl)-2-furoyl]hydrazine 
• 1410785-80-6 C₁₈H₁₀ClFN₂O₂ 

Relevant academic research and scientific papers

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

2-furoylamide compound and preparation and application thereof

The invention discloses a 2-furancarboxamide compound and a preparation method and application thereof. The 2-furancarboxamide compound is obtained by reacting a compound as shown in a formula II with9H-pyridino[3,4-b]indole in the presence of an acid-bin

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Cyclic amino substituted 5-arylfuran-2-carboxamide, preparation method thereof, and pharmaceutical composition for use in preventing or treating Urotensin-Ⅱ receptor activity related diseases containing the same as an active ingredient

The present invention relates to a 5-arylfuran-2-carboxamide derivative substituted with a cyclic amine group, a production method thereof, and a pharmaceutical composition for preventing or treating diseases associated with urotensin-II receptor activation containing same as an active ingredient. According to the present invention, the 5-arylfuran-2-carboxamide derivative substituted with the cyclic amine group acts as an antagonist to urotensin-II receptors, and thus can be useful for preventing or treating diseases associated with urotensin-II receptor activation such as congestive heart failure, ischemic heart disease, cardiac infarction, cardiac hypertrophy, myofibrosis cordis, coronary heart disease, arteriosclerosis, hypertension, asthma, renal failure, diabetes, vascular inflammation, neurodegenerative disease, stroke, pain, depression, psychosis, and cancer.COPYRIGHT KIPO 2018

Synthesis of carbohydrazides and carboxamides as anti-tubercular agents

A novel series of furan/thiophene carbohydrazides and carboxamides were synthesized and evaluated for anti-TB and cytotoxic activities. All the synthesized compounds were characterized using 1H and 13C NMR and mass spectral technique

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains