73279-38-6 Usage
Description
(+/-)5-HETE METHYL ESTER, also known as (±)5-HETE, is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The methyl ester of (±)5-HETE has no distinguishing biological activity and is primarily supplied as a standard for various applications. It is derived from oxidatively degraded polyunsaturated fatty acid (PUFA) methyl esters, which may contain (±)5-HETE methyl ester.
Uses
Used in Research and Development:
(+/-)5-HETE METHYL ESTER is used as a research compound for studying the role of monohydroxy fatty acids in various biological processes and their potential applications in the field of medicine and pharmacology. Its standard form makes it a valuable tool for comparing and analyzing the properties of related compounds.
Used in Quality Control:
In the pharmaceutical and biotechnology industries, (+/-)5-HETE METHYL ESTER is used as a quality control standard to ensure the accuracy and reliability of analytical methods and techniques employed in the identification and quantification of related compounds.
Used in Analytical Chemistry:
(+/-)5-HETE METHYL ESTER serves as a reference material in analytical chemistry, particularly in the development and validation of chromatographic and mass spectrometry methods for the separation, identification, and quantification of monohydroxy fatty acids and their derivatives.
Used in Lipidomics:
In the field of lipidomics, (+/-)5-HETE METHYL ESTER is utilized as a reference compound for the comprehensive analysis of lipids and their role in cellular processes, as well as for understanding the changes in lipid profiles under various physiological and pathological conditions.
Used in Drug Discovery:
(+/-)5-HETE METHYL ESTER may be employed in drug discovery efforts, particularly in the search for novel therapeutic agents targeting lipid metabolism and related pathways. Its structural and functional characteristics can provide insights into the design and optimization of potential drug candidates.
Used in Nutritional Science:
In nutritional science, (+/-)5-HETE METHYL ESTER can be used to study the effects of dietary fatty acids on health and disease, as well as to investigate the role of lipids in the regulation of metabolic processes and the maintenance of overall health.
Used in Industrial Applications:
(+/-)5-HETE METHYL ESTER may also find applications in the development of novel materials and products in various industries, such as the food, cosmetic, and pharmaceutical industries, where its unique properties can be harnessed for specific purposes, such as improving the stability, texture, or bioavailability of products.
Check Digit Verification of cas no
The CAS Registry Mumber 73279-38-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,2,7 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 73279-38:
(7*7)+(6*3)+(5*2)+(4*7)+(3*9)+(2*3)+(1*8)=146
146 % 10 = 6
So 73279-38-6 is a valid CAS Registry Number.
73279-38-6Relevant articles and documents
Synthesis of 5-(S)-HETE, 5-(S)-HEPE and (+)-zooxanthellactone: Three hydroxylated polyunsaturated fatty acid metabolites
Primdahl, Karoline Gangestad,Stenstr?m, Yngve,Hansen, Trond Vidar,Vik, Anders
, p. 1 - 4 (2016)
Short and stereoselective syntheses of the two hydroxylated polyunsaturated fatty acid metabolites, namely 5-(S)-HETE and 5-(S)-HEPE, are reported in 23% and 30% overall yields, respectively. In addition, synthesis of the polyunsaturated fatty acid natura
Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5 S-HETE by native and aspirin-acetylated COX-2
Mulugeta, Surafel,Suzuki, Takashi,Hernandez, Noemi Tejera,Griesser, Markus,Boeglin, William E.,Schneider, Claus
experimental part, p. 575 - 585 (2010/09/04)
Biosynthesis of the prostaglandin endoperoxide by the cyclooxygenase (COX) enzymes is accompanied by formation of a small amount of 11 R- hydroxyeicosatetraenoic acid (HETE), 15 R-HETE, and 15 S-HETE as by-products. Acetylation of COX-2 by aspirin abrogates prostaglandin synthesis and triggers formation of 15 R-HETE as the sole product of oxygenation of arachidonic acid. Here, we investigated the formation of by-products of the transformation of 5 S-HETE by native COX-2 and by aspirin-acetylated COX-2 using HPLC-ultraviolet, GC-MS, and LC-MS analysis. 5 S,15 S-dihydroxy (di)HETE, 5 S,15 R-diHETE, and 5 S,11 R-diHETE were identified as by-products of native COX-2, in addition to the previously described di-endoperoxide (5 S,15 S-dihydroxy-9 S,11 R,8 S,12 S-diperoxy-6 E,13 E-eicosadienoic acid) as the major oxygenation product. 5 S,15 R-diHETE was the only product formed by aspirinacetylated COX-2. Both 5,15-diHETE and 5,11-diHETE were detected in CT26 mouse colon carcinoma cells as well as in lipopolysaccharide-activated RAW264.7 cells incubated with 5 S-HETE, and their formation was attenuated in the presence of the COX-2 specific inhibitor, NS-398. Aspirintreated CT26 cells gave 5,15-diHETE as the most prominent product formed from 5 S-HETE. 5 S,15 S-diHETE has been described as a product of the cross-over of 5-lipoxygenase (5-LOX) and 15-LOX activities in elicited rat mononuclear cells and human leukocytes, and our studies implicate crossover of the 5-LOX and COX-2 pathways as an additional biosynthetic route. Copyright
Synthesis of polyconjugated fatty acids
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Page 3; 12, (2010/02/10)
The present invention relates to fatty acids. In particular, the present invention provides polyconjugated fatty acids, and methods of their synthesis and their use.
