73281-79-5Relevant academic research and scientific papers
Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway
Alfonsi, Romina,Botta, Bruno,Cacchi, Sandro,Di Marcotullio, Lucia,Fabrizi, Giancarlo,Faedda, Roberta,Goggiamani, Antonella,Iazzetti, Antonia,Mori, Mattia
, p. 1469 - 1477 (2017)
2-Substituted 3-aroylquinolin-4(1H)-ones, prepared through a palladium-catalyzed carbonylative cyclization of N-(2-iodoaryl)enaminones, proved to inhibit efficiently the Hedgehog pathway through direct antagonism of the wild-type and drug-resistant form o
