73305-14-3

Upstream product

• 23165-64-2 2-chloro-4-nitrophenyl isothiocyanate 

Downstream Products

• 73311-09-8 (2-chloro-4-nitro-phenyl)-(5-ethylsulfanyl-[1,3,4]thiadiazol-2-yl)-amine 
• 70974-29-7 (2-chloro-4-nitro-phenyl)-[1,2,3,4]thiatriazol-5-yl-amine 
• 68161-66-0 5-(2-chloro-4-nitro-anilino)-3H-[1,3,4]thiadiazole-2-thione 
• 107450-55-5 1-(2-Chloro-4-nitro-phenyl)-1H-tetrazole-5-thiol 

Relevant academic research and scientific papers

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

With the aim to explore the interest of the thiosemicarbazide scaffold for the inhibition of the indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target for anticancer immunotherapy, a series of 32 phenylthiosemicarbazide derivatives was prepared and their IDO inhibition evaluated. Our study demonstrated that among these derivatives, compound 14 characterized with a 4-cyanophenyl group on the thiosemicarbazide was the more potent IDO inhibitor in this series being endowed with an IC50 of 1.2 μM. The SAR depicted showed that substitution in the 3- and 4-position relative to the phenylthiosemicarbazide are very promising whereas substitution in the 2-position always leads to less potent or inactive derivatives. In fact the study highlighted a novel interesting scaffold for IDO inhibition for further development.