733050-11-8Relevant academic research and scientific papers
Design, synthesis and evaluation of 2′-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents
Cao, Ruiyuan,Fan, Shiyong,Li, Song,Li, Wei,Li, Xiaoyuan,Li, Yuexiang,Yan, Linjie,Zhang, Hongjie,Zhong, Wu
supporting information, (2021/09/28)
A series of phosphoamidate derivatives of nucleoside 2′-acetylene-7-deaza-adenosine (NITD008) were synthesized and evaluated for their in vitro antiviral activities against the enteroviruses EV71 and EV-D68. The phosphoamidate (15f) containing a hexyl est
2′-deoxy-2′-α-C-(hydroxymethyl)adenosine as potential anti-HCV agent
Chavain, Natascha,Herdewijn, Piet
experimental part, p. 1140 - 1147 (2011/03/22)
Because of the importance of C-branched nucleosides in the discovery of new antiviral molecules, we decided to synthesize 2′-deoxy-2′-α- C-(hydroxymethyl)adenosine as a potential anti-HCV agent. The synthesis of a new adenosine analogue following two different synthetic routes is described. The new C-branched nucleoside was tested for its antiviral activity and found to be inactive.
Synthesis of nucleosides with additional nucleobases
Andersen, Charlotte,Pedersen, Soren L.,Nielsen, Poul
, p. 1435 - 1438 (2008/09/18)
The syntheses of two nucleosides with additional nucleobases in the 2′-position are presented. The nucleosides have two- and one-carbon linkers to the additional nucleobase, respectively. The two nucleosides are synthesized from different strategies. The
Synthesis of the phosphoramidite derivatives of 2′-deoxy-2′-C- α-methylcytidine and 2′deoxy-2′-C- αhydroxymethylcytidine: Analogues for chemical dissection of RNA's 2′-hydroxyl group
Li, Nan-Sheng,Piccirilli, Joseph A.
, p. 4751 - 4759 (2007/10/03)
Oligonucleotides containing 2′-C-αmethyl and 2′-C-α-hydroxymethyl modifications enable strategies for delineation of the distinctive role fulfilled by the 2′-hydroxyl group in RNA structure and function. Synthetic routes to the phosphoramidite derivatives
Synthesis and antiviral evaluation of 2'-deoxy-2'-C-trifiuoromethyl beta-D-ribonucleoside analogues bearing the five naturally occurring nucleic acid bases.
Jeannot, Frederic,Gosselin, Gilles,Mathe, Christophe
, p. 2096 - 2102 (2007/10/03)
2'-Deoxy-2'-C-trifluoromethyl-beta-D-ribonucleoside derivatives bearing the five naturally occurring acid bases have been synthesized. All these derivatives were prepared by glycosylation reactions of purine and pyrimidine bases with a suitable peracylated 2-deoxy-2-C-trifluoromethyl sugar precursor to afford anomeric mixtures of protected nucleosides. After separation and deprotection, the resulting beta-nucleoside analogues were tested for their activity against HIV, HBV and several RNA viruses. However, none of these compounds showed significant antiviral activity nor cytotoxicity.
