73313-17-4Relevant academic research and scientific papers
An interdisciplinary approach to the design of new structures active at the β-adrenergic receptor. Aliphatic oxime ether derivatives
Macchia,Balsamo,Lapucci,Martinelli,Breschi,Fantoni,Martinotti
, p. 153 - 160 (1985)
On the basis of results previously obtained from structural and theoretical studies on β-adrenergic drugs, a series of aliphatic oxime ether derivatives (AOEDs) was synthesized. As expected, pharmacological in vitro tests showed that compounds examined ex
Synthesis and β-Adrenergic Blocking Activity of New Aliphatic Oxime Ethers
Leclerc, Gerard,Bieth, Nicole,Schwartz, Jean
, p. 620 - 624 (2007/10/02)
New β-adrenergic blocking agents, most of which do not contain an aromatic nucleus, were synthesized.They were derived either from alkylamino-aliphatic oxime ethers, or alkylamino-aliphatic ethers.Most active among these are O-acetoxime (8; trachea pA2=7.65) and 1-isobutoxy-3-(tert-butylamino)-2-propanol (15, trachea pA2=7.49), both of which displayed bronchoselectivity (β2/β1 ratio ca. 15).The role and importance of the aromatic nucleus in this class of compounds are discussed
