73318-46-4Relevant academic research and scientific papers
Convenient synthesis of unsymmetrical N,N′-disubstituted thioureas in water
Li, Zhengyi,Chen, Yuan,Yin, Yue,Wang, Zhiming,Sun, Xiaoqiang
, p. 670 - 673 (2016/11/18)
A simple and convenient two-step method has been developed and used to synthesise 25 (4 of which are novel) unsymmetrical N,N′-disubstituted thioureas in water. Alkylamines or variously substituted arylamines reacted smoothly with phenyl chlorothionoformate at room temperature to form thiocarbamates, which were then reacted with another alkyl- or arylamine in water at reflux to afford the unsymmetrical N,N′-disubstituted thioureas in good to excellent yields. Mild conditions, simple work-up, high yields as well as using water as solvent are the major advantages of the method.
Trapping Reactive Intermediates by Mechanochemistry: Elusive Aryl N-Thiocarbamoylbenzotriazoles as Bench-Stable Reagents
?trukil, Vjekoslav,Gracin, Davor,Magdysyuk, Oxana V.,Dinnebier, Robert E.,Fri??ic, Tomislav
supporting information, p. 8440 - 8443 (2015/11/27)
Monitoring of mechanochemical thiocarbamoylation by in situ Raman spectroscopy revealed the formation of aryl N-thiocarbamoylbenzotriazoles, reactive intermediates deemed unisolable in solution. The first-time isolation and structural characterization of these elusive molecules demonstrates the ability of mechanochemistry to access otherwise unobtainable intermediates and offers a new range of masked isothiocyanate reagents.
A new and efficient solid state synthesis of diaryl thioureas
Li,Wang,Wang,Luo,Wang
, p. 781 - 785 (2007/10/03)
Fourteen diaryl thioureas which are physiologically active have been synthesized in the solid state at room temperature. The reaction needs only simple equipment and gives excellent yields.
