73340-44-0

Usage

Uses

Used in Pharmaceutical Industry:
3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone is used as a pharmaceutical agent for its potential anti-inflammatory, antioxidant, and anti-cancer properties. Its unique chemical structure allows it to modulate various biological pathways and exhibit inhibitory effects on inflammation, oxidative stress, and cancer cell growth, making it a valuable compound for the development of novel therapeutic agents.
Used in Functional Foods:
3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone is used as a functional food ingredient to provide health benefits beyond basic nutrition. Its antioxidant and anti-inflammatory properties can contribute to the prevention of chronic diseases and promote overall health and well-being. Incorporating 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone into functional foods can help consumers obtain these benefits through their daily diet.
Further research is needed to fully understand the potential benefits and mechanisms of action of 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone, as well as to explore its applications in other industries such as cosmetics and nutraceuticals.

InChI:InChI=1/C21H20O9/c1-23-13-6-10(7-14-16(13)29-9-28-14)12-8-11(22)15-17(24-2)19(25-3)21(27-5)20(26-4)18(15)30-12/h6-8H,9H2,1-5H3

Upstream product

• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 
• 76015-47-9 7-methoxy-benzo[1,3]dioxole-5-carbonyl chloride 

Downstream Products

• 526-34-1 5-methoxy-3,4-methylenedioxybenzoic acid 
• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 

Relevant academic research and scientific papers

Synthesis of Polymethoxyflavonoids from Hesperidin and Naringin and their Antiproliferative Activity

[Figure not available: see fulltext.] A series of polymethoxyflavonoids were synthesized via cleavage of the glycosidic bond, dehydrogenation, selective methylation, bromination, nucleophilic aromatic substitution, O-prenylation, Claisen–Schmidt aldol condensation, cyclization, and oxidation from very abundant and inexpensive natural flavonoids hesperidin and naringin. The in vitro antiproliferative activity of the synthesized compounds was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2, and SUN-5) by the CellTiter-Glo assay. The results showed that some of synthesized compounds exhibited moderate to high antiproliferative activity. Among them, (2E)-1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(7-methoxy-1,3-benzodioxol-5-yl)prop-2-en-1-one was revealed to be the most active with IC50 values ranging from 10.35 to 13.89 μM against all four cancer cell lines, the IC50 value (10.35 μM) being below positive control cisplatin (12.36 μM) against HepG-2 cells.

ISOLATION AND SYNTHESIS OF TWO NEW FLAVONES FROM CONOCLINIUM COELESTINUM

Two new flavones, 3',4'-methylenedioxy-5,6,7,8,5'-pentamethoxyflavone and 5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone, have been isolated from Conoclinium coelestinum.Final structure proof was accomplished by synthesis.Key Word Index - Conoclinium coelestinum; Compositae; Eupatorieae; flavones; 3',4'-methylenedioxy-5,6,7,8,5'-pentamethoxyflavone; 5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone.