3162-28-5Relevant articles and documents
Biotransformation of polymethoxylated flavonoids: Access to their 4′-O-demethylated metabolites
Buisson, Didier,Quintin, Jerome,Lewin, Guy
, p. 1035 - 1038 (2007)
Regioselective O-demethylation of the flavones tangeretin (1) and 3-hydroxytangeretin (6) into their 4′-O-demethylated metabolites was performed by using an Aspergillus niger strain. This method serves as a straightforward alternative to multistep synthes
preparing methods of nobiletin
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Paragraph 0142-0143; 0164-0166, (2021/08/24)
The present invention provides a process for preparing nobiletin. The present invention relates to a method for preparing nobiletin by using a specific reagent.
Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives
Asakawa, Tomohiro,Sagara, Hiroto,Kanakogi, Masaki,Hiza, Aiki,Tsukaguchi, Yuta,Ogawa, Takahiro,Nakayama, Miho,Ouchi, Hitoshi,Inai, Makoto,Kan, Toshiyuki
, p. 595 - 602 (2019/04/01)
We present a practical synthesis of the polymethoxylated citrus flavone nobiletin that is suitable for use on a hundred gram scale. Ready availability of this compound and its derivatives will aid detailed chemical-biological investigations of their biological activities, including activation of signaling via the cAMP-dependent protein kinase A/extracellular signal-related protein kinase/cAMP response element-binding protein pathway.
Synthesis and Antiproliferative Activity of Natural and Non-Natural Polymethoxychalcones and Polymethoxyflavones
Vongdeth, Kingsadingthongkham,Han, Peipei,Li, Wei,Wang, Qiu-An
, p. 11 - 17 (2019/03/21)
Two series of polymethoxychalcones and polymethoxyflavones, including the natural products 2′-hydroxy-3,4,5,4′,6′-pentamethoxychalcone (8c), 5,6,7,8,3′,4′,5′-heptamethoxyflavone (6), 5,7,3′,4′,5′-pentamethoxyflavone (9c), 3-hydroxy-5,6,7,8,3′,4′,5′-heptam
Nobiletin derivative or pharmaceutically acceptable salt thereof as well as preparation method and application thereof
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Paragraph 0129-0131; 0133, (2019/12/09)
The invention discloses a nobiletin derivative or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The nobiletin derivative has a structural formula(I) shown in the description, in the formula, R1, R2, R3 and R4 are respectively selected from hydrogen, halogen, hydroxyl, amino, C1-6 substituted or non-substituted alkoxy, a C1-6 substituted or non-substituted ester group, C1-6 substituted or non-substituted alkamino and a C1-6 substituted or non-substituted amide group; R5 is selected from a C3-9 substituted or non-substituted aromatic ring and a C3-9 substituted or non-substituted aromatic heterocyclic ring; and X is selected from O or NR6. The nobiletin derivative or the pharmaceutically acceptable salt thereof, which is disclosed by theinvention, is novel in structure, and in addition, the compound has an excellent inhibition function on P-gp, can be prepared into a P-gp inhibitor, is capable of treating and/or preventing related diseases caused by P-gp, particularly diseases related to tumor drug resistance, or can be mixed and used with other medicines and used as a drug resistance reversal agent, has a high reversion multiple, and is capable of remarkably improving medicine effects of medicines.
Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production
Oshitari, Tetsuta,Okuyama, Yuji,Miyata, Yoshiki,Kosano, Hiroshi,Takahashi, Hideyo,Natsugari, Hideaki
scheme or table, p. 4540 - 4544 (2011/09/12)
A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydro
PET imaging of nobiletin based on a practical total synthesis
Asakawa, Tomohiro,Hiza, Aiki,Nakayama, Miho,Inai, Makoto,Oyama, Dai,Koide, Hiroyuki,Shimizu, Kosuke,Wakimoto, Toshiyuki,Harada, Norihiro,Tsukada, Hideo,Oku, Naoto,Kan, Toshiyuki
supporting information; experimental part, p. 2868 - 2870 (2011/04/22)
A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of 11C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease. The Royal Society of Chemistry.
COGNITIVE DISORDER-AMELIORATING AGENT
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, (2011/05/04)
A cognitive impairment ameliorant is provided that is useful for the prevention or treatment of cognitive impairment, and particularly Alzheimer's disease. The cognitive impairment ameliorant contains royal jelly as an active ingredient thereof.
Synthesis and biological evaluation of a series of tangeretin-derived chalcones
Quintin, Jerome,Desrivot, Julie,Thoret, Sylviane,Menez, Patrick Le,Cresteil, Thierry,Lewin, Guy
scheme or table, p. 167 - 169 (2009/04/10)
A series of chalcones polyoxygenated on the ring A (with pentamethoxy or 2′-hydroxy-3′,4′,5′,6′-tetramethoxy substitution patterns) was synthesized from tangeretin, a natural Citrus flavonoid. These chalcones were evaluated for their antiproliferative, ac
Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones
Quintin, Jerome,Buisson, Didier,Thoret, Sylviane,Cresteil, Thierry,Lewin, Guy
scheme or table, p. 3502 - 3506 (2010/04/26)
A series of 3′-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition
