73344-39-5

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

It is a heterocyclic compound containing both a benzene ring and an isoxazole ring.

Explanation

The presence of these functional groups at the 6th and 3rd positions, respectively, differentiates 1,2-BENZISOXAZOLE, 6-METHOXY-3-METHYL- from other benzisoxazole derivatives.

Explanation

It is a solvent with a high level of purity, making it suitable for use in various chemical reactions and processes.

Explanation

It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique chemical properties.

Explanation

The compound is also used in the production of dyes and pigments, taking advantage of its chemical structure and properties.

Explanation

Due to its unique structure and properties, it has potential applications in the development of new materials and in organic synthesis, which could lead to the creation of novel compounds and products.

Explanation

The solubility of the compound in different solvents is not mentioned in the provided material, but it is an important property to consider for its applications.

Explanation

The stability of the compound under various conditions (e.g., temperature, pressure, light exposure) is not mentioned in the provided material, but it is a crucial factor for its practical applications.

Explanation

The reactivity of the compound with other chemicals or under specific conditions is not mentioned in the provided material, but it is an essential aspect to consider for its use in chemical reactions and processes.

Chemical Structure

1,2-Benzisoxazole derivative

Functional Groups

Methoxy (-OCH3) and Methyl (-CH3)

Classification

High-purity solvent

Applications

Pharmaceutical and agrochemical synthesis

Applications

Dyes and pigments production

Potential Applications

Development of new materials and organic synthesis

Upstream product

• 1021267-09-3 2'-hydroxy-4'-methoxyacetophenone imine 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 66033-92-9 6-hydroxy-3-methyl-1,2-benzisoxazole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1394900-13-0 benzyl 1-(2-hydroxy-4-methoxyphenyl)-1-ethylcarbamate 
• 145508-55-0 6-methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole 

Relevant academic research and scientific papers

A kind of benzo [d] different wicked zuozuo apperception compound and use thereof

The invention relates to the technical field of chemical medicine, and particularly discloses a benzo[d]isoxazole compound shown as a general formula (A) and application thereof. The compound can effectively inhibit bromodomain of BET family proteins so as to block interaction between the BET family proteins and chromatin histone to adjust genetic transcription, cause changing of a downstream signal path and exert important influence on various diseases, so that the compound and a combination thereof can be used for preparing medicine for treating or preventing diseases like tumorigenesis, inflammation, viral infection, cell proliferation disorder, autoimmune diseases and septicemia.

Method for preparing benzisoxazole in one pot based on 2-hydroxyacetophenone oxime and derivatives thereof

The invention relates to the technical field of medicinal chemistry and in particular discloses a method for preparing benzisoxazole in one pot based on 2-hydroxyacetophenone oxime and derivatives thereof. The preparation method is as follows: under microwave or oil bath heating conditions, in an organic solvent, one-pot inversion is carried out on 2-hydroxyacetophenone oxime and derivatives thereof to form benzisoxazole compounds by utilizing a fluorine-containing accelerator and alkali. The method for synthesizing benzisoxazole has the advantages that raw materials are rich in source and easy to get, synthetic steps are short, the operation is simple and convenient, the product yield is high, and the highest yield is 93%. A benzisoxazole structure exists in multiple drug molecules, so that the novel one-pot synthesis method disclosed by the invention has potential practical values.

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine

A divergent and regioselective synthesis of either 3-substituted benzisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, respectively. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed.

Antitubercular Agents: Part VI- Alkoxy Derivatives of 6-Hydroxy-3-methyl-1,2-benzisoxazole

Several alkoxy derivatives of 6-hydroxy-3-methyl-1,2-benzisoxazoles have been synthesised and screened for their antitubercular activity for QSAR studies.