73344-39-5

Basic information

• Product Name: 1,2-BENZISOXAZOLE, 6-METHOXY-3-METHYL-
• Synonyms: 1,2-BENZISOXAZOLE, 6-METHOXY-3-METHYL-;1,2-Benzisoxazole,6-methoxy-3-methyl-(9CI);6-Methoxy-3-methyl-1,2-benzisoxazole;6-Methoxy-3-methyl-benzo[d]isoxazole
• CAS NO: 73344-39-5
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17326
• Product Categories: OXAZOLE
• Mol File: 73344-39-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 96-97℃
• Appearance: /
• CAS DataBase Reference: 1,2-BENZISOXAZOLE, 6-METHOXY-3-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BENZISOXAZOLE, 6-METHOXY-3-METHYL-(73344-39-5)
• EPA Substance Registry System: 1,2-BENZISOXAZOLE, 6-METHOXY-3-METHYL-(73344-39-5)

Safety Data

• Hazardous Substances Data: 73344-39-5(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazole, 6-methoxy-3-methyl- is a chemical compound with the molecular formula C9H9NO2. It is a derivative of benzisoxazole, a heterocyclic compound containing both a benzene ring and an isoxazole ring. This chemical is classified as a high-purity solvent and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. Additionally, 1,2-benzisoxazole, 6-methoxy-3-methyl- has potential applications in the development of new materials and in organic synthesis.

Upstream product

• 66033-92-9 6-hydroxy-3-methyl-1,2-benzisoxazole 
• 77-78-1 dimethyl sulfate 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 1021267-09-3 2'-hydroxy-4'-methoxyacetophenone imine 

Downstream Products

• 145508-55-0 6-methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole 
• 1394900-13-0 benzyl 1-(2-hydroxy-4-methoxyphenyl)-1-ethylcarbamate 

Relevant articles and documents

A kind of benzo [d] different wicked zuozuo apperception compound and use thereof

The invention relates to the technical field of chemical medicine, and particularly discloses a benzo[d]isoxazole compound shown as a general formula (A) and application thereof. The compound can effectively inhibit bromodomain of BET family proteins so as to block interaction between the BET family proteins and chromatin histone to adjust genetic transcription, cause changing of a downstream signal path and exert important influence on various diseases, so that the compound and a combination thereof can be used for preparing medicine for treating or preventing diseases like tumorigenesis, inflammation, viral infection, cell proliferation disorder, autoimmune diseases and septicemia.

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine

A divergent and regioselective synthesis of either 3-substituted benzisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, respectively. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed.