733724-68-0

Upstream product

• 39743-20-9 1-(3-chloropropyl)pyrrolidine 
• 205448-31-3 4-chloro-6-methoxy-7-hydroxyquinoline 

Downstream Products

• 1394165-59-3 N-(3-fluoro-4-((6-methoxy-7-(3-(4-methyl-piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(4-fluorophenyl)-1,4-dihydroquinoline-3-carboxamide 

Relevant academic research and scientific papers

MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS

Pharmaceutical compositions of the invention comprise TDP-43 binding agents having a disease-modifying action in the treatment of diseases associated with TDP-43 that include ALS, FTLD, CTE, hippocampal sclerosis of aging (CARTS), Alzheimers disease, and Alzheimers disease related disorder, and disease that involve excess amounts of TDP-43 in the cytosol.