4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

Base Information

• Chemical Name: 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
• CAS No.: 733724-68-0
• Molecular Formula: C₁₇H₂₁ClN₂O₂
• Molecular Weight: 320.819
• Mol file: 733724-68-0.mol

Synonyms:4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

Chemical Property of 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

There total 1 articles about 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-(3-chloropropyl)pyrrolidine (39743-20-9) + 4-chloro-6-methoxy-7-hydroxyquinoline (205448-31-3) → 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline (733724-68-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 86.3%

4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline (733724-68-0) + 2-fluoro-4-nitrophenol (403-19-0) → 4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline (1394166-10-9)

Guidance literature:

In chlorobenzene; at 140 ℃; for 30h;

DOI:10.1016/j.bmc.2013.04.013

Reference yield: 71.5%

4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline (733724-68-0) + (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester (79280-92-5) → methyl 2-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)acetate

Guidance literature:

In chlorobenzene; at 140 ℃; for 30h;

DOI:10.1016/j.ejmech.2014.09.095

upstream raw materials:

1-(3-chloropropyl)pyrrolidine

4-chloro-6-methoxy-7-hydroxyquinoline

Downstream raw materials:

4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

N-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1-(3-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide