73374-11-5Relevant academic research and scientific papers
Unexpected one-step synthesis of 3-benzoyl-2-phenylbenzofurans under Wittig conditions
Begala, Michela,Caboni, Pierluigi,Matos, Maria Jo?o,Delogu, Giovanna Lucia
, p. 1711 - 1714 (2018)
The reaction of 2-hydroxybenzyltriphenylphosphonium bromide with substituted benzoyl chlorides under Wittig conditions, led to 2-phenylbenzofuran derivatives 4a–p and the unexpected formation of 3-benzoyl-2-phenylbenzofuran derivatives 5a–p. Benzoyl chlorides possessing electron-withdrawing groups afforded 3-benzoyl-2-phenylbenzofuran derivatives in higher yields than those with electron-donating groups. This reaction represents a simple and regioselective, one-pot route towards the preparation of deactivated 3-benzoyl-2-phenylbenzofuran compounds which are difficult to obtain by the direct acylation of 2-phenylbenzofurans.
Unexpected migration of a benzoyl group in the intramolecular Wittig reaction of o-acyloxybenzylidenephosphoranes with benzoyl chlorides: One-pot synthesis of isomeric 3-benzoyl-2-phenylbenzofurans
Begala, Michela,Mancinelli, Michele,Delogu, Giovanna Lucia
supporting information, (2020/01/28)
The reaction of o-acyloxybenzylidenetriphenylphosphoranes with substituted benzoyl chlorides in an aprotic solvent led, together with the expected 2-phenylbenzofuran, to isomeric 3-benzoyl-2-phenylbenzofuran derivatives. This result formally corresponds to intramolecular migration of the benzoyl group from the ortho oxygen atom to the ylide carbanion via cyclization and ring opening of the starting o-acyloxybenzylidenetriphenylphosphoranes.
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase
Woon, Esther C. Y.,Demetriades, Marina,Bagg, Eleanor A. L.,Aik, Weishen,Krylova, Svetlana M.,Ma, Jerome H. Y.,Chan, Munchiang,Walport, Louise J.,Wegman, David W.,Dack, Kevin N.,McDonough, Michael A.,Krylov, Sergey N.,Schofield, Christopher J.
supporting information; experimental part, p. 2173 - 2184 (2012/05/20)
2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of these enzymes are linked to physiology, their regulatory roles are unclear. Hence, there is a de
A novel photochemical Wittig reaction for the synthesis of 2-aryl/alkylbenzofurans
Ghosh, Somnath,Das, Jhantu
scheme or table, p. 1112 - 1116 (2011/03/22)
The synthesis of 2-aryl/alkylbenzofurans has been achieved in high yields under photochemical conditions from readily accessible and suitably substituted phosphonium bromides by an intramolecular photochemical Wittig reaction onto aryloxycarbonyl groups.
Antiosteoporotic imidazo[4,5-c]pyridines
-
, (2008/06/13)
This invention relates to 2-substituted-imidazo[4,5 -c]pyridines, to the process for their preparation, to pharmaceutical compositions containing said 2-substituted-imidazo]4,5-c]pyridines and to the use of said 2-substituted-imidazo[4,5-c]pyridines for modifying the balance between bone production and bone resorption in a host animal, including man.
