733758-24-2Relevant academic research and scientific papers
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Chen, Ping,Caldwell, Charles G.,Mathvink, Robert J.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,He, Huaibing,Lyons, Kathryn A.,Thornberry, Nancy A.,Weber, Ann E.
, p. 5853 - 5857 (2007)
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4.
