733758-27-5 Usage
Uses
Used in Pharmaceutical Industry:
tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate is used as a key intermediate in the synthesis of 3-Amino-4-phenylbutanoic Acid derivatives. These derivatives act as inhibitors of the dipeptidyl peptidase-IV (DPP-IV) enzyme, which plays a crucial role in the regulation of glucose homeostasis. By inhibiting DPP-IV, these compounds can help in the treatment or prevention of diseases such as diabetes, particularly type-2 diabetes.
Used in Chemical Research:
Due to its unique structure and functional groups, tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate can be employed as a building block in the development of new chemical entities with potential applications in various fields. Researchers can use tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate to explore its reactivity, stability, and other properties, which may lead to the discovery of novel compounds with improved pharmacological profiles or industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 733758-27-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,3,7,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 733758-27:
(8*7)+(7*3)+(6*3)+(5*7)+(4*5)+(3*8)+(2*2)+(1*7)=185
185 % 10 = 5
So 733758-27-5 is a valid CAS Registry Number.
733758-27-5Relevant academic research and scientific papers
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Chen, Ping,Caldwell, Charles G.,Mathvink, Robert J.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,He, Huaibing,Lyons, Kathryn A.,Thornberry, Nancy A.,Weber, Ann E.
, p. 5853 - 5857 (2008/04/03)
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4.
