73386-22-8

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 107918-07-0 2,3-dihydro-2-(2-nitrophenyl)-4H-1-benzopyran-4-one 
• 70170-88-6 C₁₅H₉NO₄ 
• 53277-26-2 2'-nitro-Flavone 
• 612-41-9 2-nitrocinnamic acid 
• 72195-26-7 2-(2-hydroxyphenyl)quinoline-N-oxide 
• 42731-96-4 2-quinolin-2-yl-phenol 

Relevant academic research and scientific papers

Glycolytic inhibition and antidiabetic activity on synthesized flavanone scaffolds with computer aided drug designing tools

Background: Diabetes mellitus is a challengeable metabolic disorder that leads to a group of complications when the HbA1c level is not maintained. Most of the existing drugs avail-able in the market in long-term use may lead to serious adverse effects. He

Differences in antioxidant potential of chalcones in human serum: In vitro study

Introduction: An imbalance between oxidants and antioxidants in favour of oxidants, potentially leading to damage, is termed oxidative stress. Antioxidants (AO), either enzymatic or non-enzymatic, are the ones that can reduce diverse effects of pro-oxidan

Iron(III) catalyzed direct C–H functionalization at the C-3 position of chromone for the synthesis of fused chromeno-quinoline scaffolds

This communication describes an iron-catalyzed route for the synthesis of 6-substituted chromeno[3,2-c]quinolin-7-one. The method developed does not require any pre-functionalization to execute the pivotal coupling reaction at the C-3 position of flavones

Synthesis of some modified aurones as antileukemic and antibacterial agents

Cyclisation of 1-(2-hydroxyphenyl)-3-substituted phenylprop-2-en-1-ones 1a-h in pyridine with mercuric acetate gives different 2-benzylidene-1- benzofuran-3(2H)-ones 2a-h which on subsequent reaction with hydroxylamine hydrochloride affords 2-benzylidene-

Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships

A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenocarcinoma cells HT-29. The most active series is the chalcone ones with the best results against TK-10 and HT-29 cells. Fourteen out of 53 analyzed compounds resulted very active against at least two of the studied tumoral cells. Alkaline single cell gel electrophoresis, comet assay, was performed as a study of the chromosomal aberrations promoted by the compounds on normal cells. Four active and two inactive chalcones were studied in the comet assay against normal human kidney cells (HK-2). A structure-activity relationship analysis of these compounds was performed and for 4- and 3,4-disubstituted derivatives a quantitative correlation was obtained in the case of anti-HT-29 activity.

Synthesis, experimental and theoretical NMR study of 2′- hydroxychalcones bearing a nitro substituent on their B ring

The synthesis of several 2′-hydroxynitrochalcones has been accomplished by an aldol reaction of equimolar amounts of the appropriate 2′-hydroxyacetophenones with nitrobenzaldehydes in alkaline medium. The reaction of 2′-hydroxyacetophenones bearing a 6′-methoxy with 2- or 4-nitrobenzaldehydes gave the expected 2′-hydroxynitrochalcones and also 4-methoxynitroaurones, being the latter ones the unique reaction products when using 2molar equiv of nitrobenzaldehydes. The reaction mechanisms for the formation of both products are discussed. The 13C NMR chemical shifts have been discussed first by means of an empirical additive model and then by comparison with GIAO/B3LYP calculated absolute shieldings.