53277-26-2

Upstream product

• 84634-63-9 1-(2-hydroxy-phenyl)-3-(2-nitro-phenyl)-propane-1,3-dione 
• 84634-60-6 2'-(2-nitrobenzoyloxy)acetophenone 
• 95-54-5 1,2-diamino-benzene 
• 118-93-4 o-hydroxyacetophenone 
• 610-14-0 2-nitrobenzyl chloride 
• 73386-22-8 (E)-1-(2-Hydroxy-phenyl)-3-(2-nitro-phenyl)-propenone 
• 552-89-6 2-nitro-benzaldehyde 
• 552-16-9 ortho-nitrobenzoic acid 
• 73386-22-8 (E)-2'-hydroxy-2-nitrochalcone 

Downstream Products

• 70176-71-5 2-(2-aminophenyl)-4H-chromen-4-one 
• 1417515-21-9 C₁₅H₉NO₃S 
• 1417515-22-0 C₂₁H₁₃N₅O₇ 

Relevant academic research and scientific papers

Iron(III) catalyzed direct C–H functionalization at the C-3 position of chromone for the synthesis of fused chromeno-quinoline scaffolds

This communication describes an iron-catalyzed route for the synthesis of 6-substituted chromeno[3,2-c]quinolin-7-one. The method developed does not require any pre-functionalization to execute the pivotal coupling reaction at the C-3 position of flavones

Synthesis and anti-cancer activities of apigenin derivatives

A novel series of apigenin derivatives with phloroglucinol or resorcinol as raw materials were synthesized according to Baker-Venaktaraman reaction and their in vitro inhibitory activities on colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The results of biological test showed that some of apigenin derivatives possessed stronger anti-cancer activities than apigenin. Compound 6 showed the strongest activity against colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines with IC50 valure of 2.03±0.22 μM, 2.25±0.42 μM, it was better than 5-FU (12.92±0.61 μM, 9.56±0.16 μM), which shows a potezntial compound for colorectal adenocarcinoma and leucocythemia.

Structure activity relationship studies of some potent antifungal flavones, 4-thioflavones and 4-iminoflavones

A series of flavones, carrying halogens, methoxy and nitro groups at various positions were synthesized by the Baker-Venkataraman rearrangement and were subsequently converted to 4-thioflavones and 4-iminoflavones. The synthesized compounds were evaluated for their in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. All synthesized compounds showed significant activity against T. longusus, A. flavus, M. canis and F. Solani but inactive against C. albicans and C. glabrata, respectively. 2-phenyl-4H-1-benzopyran-4-thiones were relatively more active than flavones and 4-iminoflavones. However, some compounds were even more active than standard miconazol and amphotericin B drugs.

Silica-PCL5: An efficient and reusable catalyst for cyclodehydration of 1, 3-diketones to flavones

Silica-PCl5 was employed as efficient solid acid catalyst for conversion of 1, 3-diketones to flavones under solventfree condition. Reaction is simple, efficient with easy work up and the catalyst is recyclable.

Efficient synthesis of nitroflavones by cyclodehydrogenation of 2prime;-hydroxychalcones and by the Baker-Venkataraman method

Several nitroflavone derivatives were synthesized by cyclodehydrogenation of 2′-hydroxychalcones and by the Baker-Venkataraman approach, starting from 2′-hydroxyacetophenones and benzoic acid derivatives. Nitroflavones synthesised by the first synthetic a

Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor

A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.

Synthesis and characterization of 2-(2-hydroxyphenyl)-4-aryl-1,5-benzodiazepines

Four benzodiazepine derivatives, reported earlier by other authors, were resynthesized and characterized by NMR, IR, GC/MS and elemental analysis. Three of the four compounds have melting points different from those initially reported by 35-70° C. The dif