73397-20-3Relevant articles and documents
TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
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Page 4; 14-16, (2008/06/13)
The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.
Synthesis of (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoic Acid: Bridging Effect of KF
Solladie-Cavallo, A.,Khiar, N.
, p. 4750 - 4754 (2007/10/02)
Natural (2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid is synthesized in 53-55percent yield (referred to (-)-8-phenylmenthol used as chiral auxiliary) by condensation of 1-nitro-3-methylbutane on (-)-8-phenylmenthol glyoxylate hydrate using KF as a mild base.With a large excess of KF in THF it has been possible to increase the diastereoselectivity of the nitro aldol condensation (up to I/II/III/IV = 77/13/10/0).
Renin Inhibitors. Substitution of the Leucyl Residues of Leu-Leu-Val-Phe-OCH3 with 3-Amino-2-hydroxy-5-methylhexanoic Acid
Johnson, Rodney L.
, p. 605 - 610 (2007/10/02)
The 2S,3S and 2R,3S diastereoisomers of the hydroxy amino acid 3-amino-2-hydroxy-5-methylhexanoic acid (AHMHA) were synthesized and substituted for the leucyl residues of Leu-Leu-Val-Phe-OCH3 to yield the following analogues: AHMHA-Leu-Val-Phe-OCH3, AHMHA