73397-28-1

Basic information

• Product Name: N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID
• Synonyms: (2R,3S)-3-(Boc-aMino)-2-hydroxy-5-Methylhexanoic acid, 97%;(2S,3R)-3-((tert-butoxycarbonyl)aMino)- 2-hydroxy-5-Methylhexanoic acid;BOC-(2R,3S)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID;N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID
• CAS NO: 73397-28-1
• Molecular Formula: C₁₂H₂₃NO₅
• Molecular Weight: 261.31
• Mol File: 73397-28-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 419.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.125±0.06 g/cm3(Predicted)
• PKA: 3?+-.0.34(Predicted)
• CAS DataBase Reference: N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID(73397-28-1)
• EPA Substance Registry System: N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID(73397-28-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 73397-28-1(Hazardous Substances Data)

Usage

General Description

N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID is a compound with a chemical structure containing a BOC (tert-butoxycarbonyl) protecting group attached to a chiral center in the form of (2R,3S). It has a hydroxyl and amino group attached to a five-carbon chain with a methyl group, making it a hydroxy amino acid derivative. N-BOC-(2R,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID is commonly used in organic synthesis and pharmaceutical research as a building block for the production of peptides and proteins. Its chiral nature and functionality make it an important intermediate in the synthesis of various pharmaceuticals and bioactive compounds.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 73397-20-3 (2S,3S)-3-Amino-2-hydroxy-5-methylhexanoic Acid 
• 73397-22-5 Cbz-D-Leu-OMe 
• 63219-62-5 [(S)-1-((S)-Cyano-hydroxy-methyl)-3-methyl-butyl]-carbamic acid benzyl ester 
• 70853-26-8 (R)-4-methyl-1-oxopentane-2-benzylcarbamate 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 62023-30-7 (2RS,3R)-3-Amino-2-hydroxy-5-methylhexanoic Acid 
• 62023-30-7 DL-threo-3-amino-2-hydroxy-5-methylhexanoic acid 

Downstream Products

• 318464-20-9 (2R,3S)-3-amino-2-hydroxy-5-methylhexanoic acid 
• 73397-20-3 (2S,3S)-3-Amino-2-hydroxy-5-methylhexanoic Acid 
• 73397-27-0 (2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-5-methylhexanoic acid 
• 73397-25-8 (2S,3R)-3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoic Acid 
• 73397-26-9 (2R,3R)-3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoic Acid 
• 73465-23-3 (2R,3R)-(3-Amino-2-hydroxy-5-methylhexanoyl)-L-valyl-L-valyl-L-aspartic Acid 
• 67655-94-1 amastatin 
• 73397-34-9 (2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester 
• 73465-22-2 (2R,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester 

Relevant articles and documents

TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.