7340-15-0Relevant academic research and scientific papers
Design, synthesis and evaluation of D,D-peptidase and beta-lactamase inhibitors: Azapeptides, oxapeptides and related heterocycles
Marchand-Brynaert,Mougenot,Combret,Belotti,Guillot,Ghosez
, p. 455 - 469 (2007/10/02)
Reactive molecules susceptible to form stable acyl enzyme intermediates with D,D-peptidases and β-lactamases were designed as potential irreversible inhibitors of Penicillin Sensitive Enzymes (PSEs). The structures examined were a series of azapeptides and oxapeptides, both analogs of the D-Ala-D-Ala substrate, and some heterocycles, such as imidazolidinones and oxazolidinones, both analogs of the β-lactam antibiotics. The various strategies investigated for their synthesis are described and discussed. Some biological results are reported.
