32685-16-8

Usage

Uses

Used in Mining and Metallurgy Industry:
BENZOHYDROXAMIC ACID POTASSIUM SALT is used as a chelating agent for the extraction and separation of valuable metals from ores and industrial waste. Its ability to form stable complexes with metal ions aids in the efficient recovery of these metals.
Used in Pharmaceutical Production:
BENZOHYDROXAMIC ACID POTASSIUM SALT is used as a raw material in the production of pharmaceuticals. Its chelating properties contribute to the development of various pharmaceutical formulations.
Used as an Intermediate in Organic Synthesis:
BENZOHYDROXAMIC ACID POTASSIUM SALT is used as an intermediate in organic synthesis processes. Its chemical properties make it a valuable component in the synthesis of various organic compounds.

InChI:InChI=1/C7H6NO2.K/c9-7(8-10)6-4-2-1-3-5-6;/h1-5H,(H-,8,9,10);/q-1;+1

Upstream product

• 93-89-0 benzoic acid ethyl ester 
• 65-85-0 benzoic acid 

Downstream Products

• 2446-51-7 N-methoxybenzamide 
• 7340-15-0 N-Benzoyl-O-aethoxycarbonyl-hydroxylamin 
• 3532-25-0 N-benzyloxy benzamide 
• 5553-73-1 phenyl-N-(phenylmethoxy)-N-benzylcarboxamide 
• 64648-16-4 N-propoxybenzamide 
• 42832-36-0 N-Benzoyl-O-allylhydroxylamine 
• 109482-56-6 N-(2-pyridinylcarbonyloxy)benzamide 
• 23362-50-7 N-benzoyl-O-butylhydroxylamine 
• 139259-73-7 p-phenoxybenzyl benzohydroxamate 
• 112403-95-9 O-<2-(p-methoxyphenyl)ethyl> benzohydroxamate 
• 132352-75-1 O-(2-(4-bromophenyl)ethyl) benzohydroxamate 
• 112403-90-4 O-[3-(p-methoxyphenyl)-1-propyl] benzohydroxamate 
• 95207-31-1 O-3-phenylpropyl benzohydroxamate 
• 132352-74-0 O-(3-(4-methylphenyl)-1-propyl) benzohydroxamate 

Relevant academic research and scientific papers

Synthesis, characterization and assessment of local anesthetic activity of some benzohydroxamic acids

In the present investigation, 6 compounds (E1-E6) were synthesized by reaction of ethyl esters of p-substituted benzoic acid with hydroxylamine. The chemical structures of the synthesized hydroxamic acids were verified on the basis of spectral analysis (IR, 1H NMR, 13C NMR and mass spectra). The benzohydroxamic acids were examined for potential local anesthetic activity using foot withdrawal reflex of the frog and benzocaine was used as standard drug. Compounds were tested at two different solvents; 5 % DMSO and 0.65 % NaOH, each solution was tested at three different concentration levels (40, 100 and 200 μg/mL). Local anesthetic activity of the compounds differed according to the concentration level and selected solvent. Compounds E4 and E5 were found to be the most active and were comparable to the standard drug in tested solvents at all investigated concentrations. All compounds displayed an enhanced activity in the the aqueous basic solutions.

Evidence for the Formation of Nitrenium Ions in the Acid-catalysed Solvolysis of Mutagenic N-Acetoxy-N-Alkoxybenzamides

In aqueous acetonitrile, N-acetoxy-N-alkoxybenzamides undergo acid-catalysed solvolysis by the AAl1 mechanism to give acetic acid and nitrenium ions.This is indicated by an inverse dependence of the acid-independent rate constant, kH, upon the activity of water, a solvent kinetic isotope effect of 0.44 and positive Σ(excit.) values.In addition, relief of steric compression at the nitrogen enhances the rate of solvolysis.Hammett correlations with ?+ substituent constants were found for the rates of solvolysis of para-substituted-N-acetoxy-N-butoxybenzamides and N-acetoxy-N-(para-substituted benzyloxy) benzamides.This fact and the low ρ-values of -1.35 and -1.56, respectively, are indicative of a strong build-up of positive charge in the transition state which has both nitrenium ion and oxonium ion character and is in accordance with computed molecular-orbital properties of N-alkoxynitrenium ions.Greater levels of mutagenicity have been measured for those compounds which are more readily solvolysed to nitrenium ions.