73402-26-3

Upstream product

• 79222-83-6 ethyl 3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propionate 
• 59594-38-6 2-(2-Cyanoethyl)-3-oxo-6-phenyl-2,3-dihydropyridazine 
• 2166-31-6 6-phenylpyridazin-3(2H)-one 

Downstream Products

• 346407-21-4 N₁-(4-amino-1,3-dimethyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide 
• 346407-31-6 N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide 
• 1426561-22-9 N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(6-oxo-3-phenylpyridazin-1(6H)-yl)propanamide 

Relevant academic research and scientific papers

Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities

Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone- induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated t

Synthesis and analgesic and antiinflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives

For reducing gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) a variety of 6-phenyl/(4-methylphenyl)-3(2H)- pyridazinon-2-propionamide were synthesized. The structures of these new pyridazinone derivatives were confirmed by their IR, 1 H-NMR spectra and elementary analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. The analgesic activity of the test compounds was determined by phenylbenzoquinone-induced writhing assay and the anti-inflammatory activity was evaluated by the carrageenan-induced rat paw edema model. 6-Phenyl-3(2H)-pyridazinon-2-yl-[4-(4-fluorophenyl) piperazinyl] propanamide IV a-3 was the most active one among the synthesized compounds. Also this compound exhibited most potent anti-inflammatory activity. Acetylsalicylic acid and indometacin were used as reference drugs. Adverse effects of the compounds were examined on gastric mucosa. None of the compounds showed gastric ulcerogenic effect compared with the reference NSAIDs. ECV Editio Cantor Verlag.

Structure-activity relationships in a series of 8-substituted xanthines as A1-adenosine receptor antagonists

A series of 8-substituted xanthines were synthesized and their affinity in vitro towards A1, A2A-adenosine receptors was evaluated by radioligand receptor binding assays. All compounds showed a greater affinity and selectivity toward