73403-03-9

Upstream product

• 40939-26-2 {[(4-methylphenyl)sulfonyl]methyl}carbonimidic dichloride 
• 624-49-7 dimethylfumarate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 144878-85-3 C₁₅H₁₃ClN₂O₄S₂ 
• 144878-84-2 C₁₅H₁₄ClNO₂S₂ 

Relevant academic research and scientific papers

One-step synthesis of dialkyl 2-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3,4- dicarboxylates by reaction of acetylenedicarboxylates with 'tosylmethyl isocyanide' (TsMIC) and triphenylphosphine

The reactive 1:1 adducts in the reaction between Ph3P and dialkyl acetylenedicarboxylates have been trapped with 'tosylmethyl isocyanide' (TsMIC; 1) to yield dialkyl 2-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3,4- dicarboxylates 3 (Scheme 1). The

1-methylimidazole-catalyzed reaction between tosylmethyl isocyanide and dialkyl acetylenedicarboxylates: An efficient synthesis of functionalized pyrroles

An efficient 1-methylimidazole-catalyzed synthesis of dialkyl 2-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3,4-dicarboxylates is described. The reactive 1:1 zwitterionic intermediate formed by the addition of 1-methylimidazole to dialkyl acetylenedicarboxylate

Development of a Synthetic Method for Multifunctionalized Pyrroles Using Isocyanide Dichloride as a Key Intermediate

Multifunctionalized pyrrole derivatives were synthesized using a highly efficient method based on the Michael addition of carbanions generated in situ from isocyanide dichloride to α,β-unsaturated carbonyl compounds. The reactions proceeded smoothly to afford the pyrrole derivatives in good to high yields. A wide range of Michael acceptors, such as α,β-unsaturated carbonyl compounds and nitroolefin, were successfully applied to this reaction.

Base Mediated Reactions in Solid-Liquid Media. A 1,3-Dipolar Cycloaddition Route to Pyrrolines and Pyrroles from Imino Chlorosulfides.

Nitrile ylides, generated in basic conditions (HCl abstraction) from N- and N-imino chlorosulfides, undergo 1,3-dipolar cycloadditions with electron-deficient dipolarophiles to produce pyrroles and pyrrolines.Heterogeneous media are found to furnish the best conditions for these reactions.One pyrrole can also be prepared from methyl N- chlorothioimidate and dimethyl acetylenedicarboxylate on alumina-potassium fluoride mixture as solid support, under microwave irradiation. Key words: Imino chlorosulfides; alumina-dispersed potassium fluoride and potassium hydroxide; 1,3-dipolar cycloaddition; pyrroles.