73406-57-2Relevant academic research and scientific papers
Asymmetric synthesis of bioactive hydrodibenzofuran alkaloids: (-)-lycoramine, (-)-galanthamine, and (+)-lunarine
Chen, Peng,Bao, Xu,Zhang, Le-Fen,Ding, Ming,Han, Xiao-Jie,Li, Jing,Zhang, Guo-Biao,Tu, Yong-Qiang,Fan, Chun-An
, p. 8161 - 8166 (2011/10/18)
Divergent route: A direct C-C bond-forming approach to the key aryl-substituted all-carbon quaternary stereogenic center present in bioactive hydrodibenzofuran alkaloids has been discovered. This approach involves an unprecedented organocatalytic enantioselective Michael addition of α-cyanoketones with acrylates (see scheme) and was used in a novel and divergent synthetic strategy for the title compounds in asymmetric fashion.
