7341-60-8

Upstream product

• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 79-19-6 thiosemicarbazide 
• 119-61-9 benzophenone 
• 4346-94-5 thiosemicarbazide hydrochloride 

Downstream Products

• 913814-67-2 [copper(I) bromide (η1-S-benzophenone thiosemicarbazone)(triphenylphosphine)2]*acetonitrile 
• 1057413-84-9 [Ag(nitrate)(η1-S-2-benzophenone thiosemicarbazone)(triphenylphosphine)2] 
• 78514-82-6 benzophenone S-methylthiosemicarbazone 
• 78514-82-6 benzophenone S-methylthiosemicarbazone 
• 1446700-33-9 [Cl₂Ce(benzophenone thiosemicarbazone)*4H₂O] 
• 1446700-30-6 [ClLa(benzophenone thiosemicarbazone)₂*3H₂O] 
• 1446700-27-1 [Cl₂La(benzophenone thiosemicarbazone)*4H₂O] 
• 716363-88-1 3-(2-(2-(diphenylmethylene)hydrazinyl)thiazol-4-yl)-2H-chromen-2-one 
• 983-79-9 benzophenone azine 
• 5350-57-2 benzophenone hydrazone 

Relevant academic research and scientific papers

Structural and nonlinear optical properties of cross-conjugated system benzophenone thiosemicarbazone: A vibrational spectroscopic study

The nonlinear optical (NLO) compound of interest benzophenone thiosemicarbazone (BTSC) was grown and the molecular structure generated with the aid of density functional theory (DFT). FT-Raman and IR spectra were recorded and analyzed. The harmonic wavenu

Vibrational, NMR and UV-Visible spectroscopic investigation, VCD and NLO studies on Benzophenone thiosemicarbazone using computational calculations

In order to explore the unbelievable NLO property of prepared Benzophenone thiosemicarbazone (BPTSC), the experimental and theoretical investigation has been made. The theoretical calculations were made using RHF and CAM-B3LYP methods at 6-311++G(d,p) bas

Physicochemical and X-ray crystallographic properties of the first rhenium compound of benzophenone thiosemicarbazone (bptsc), fac-[Re(CO)3(κ2-Nim,S-bptsc)Cl]

fac-[Re(CO)3(κ2-Nim,S-bptsc)Cl] (2), isolated from the reaction between Re(CO)5Cl and benzophenone thiosemicarbazone, bptsc, (1) in refluxing toluene in air, is the first Re compound of 1 and is the second Re(CO

Zinc complex taking 2-benzoylpyridine thiosemicarbazone as ligand as well as synthesis method and application of zinc complex

The invention relates to a zinc complex taking 2-benzoylpyridine thiosemicarbazone as a ligand as well as a synthesis method and application of the zinc complex. The method comprises the steps of taking 2-benzoylpyridine and thiosemicarbazone, 4-methyl-3-thiosemicarbazone, 4,4'-dimethyl-3-thiosemicarbazide, 4-phenyl-3-thiosemicarbazide or 4-(2-methyl)phenyl-3-thiosemicarbazide as raw materials tosynthesize a schiff-base ligand; and reacting the ligand with zinc chloride to obtain the zinc complex. In an in-vitro test, the synthesized zinc complex has good inhibitory activity on human hepatomacarcinoma cells (HepG2), the treatment effect is superior to that of a clinical drug cis-platinum, and the zinc complex is suitable for preparing efficient antitumor drugs. In addition, the synthesized zinc complex has a good antibacterial effect on staphylococcus aureus, and is suitable for preparing antibacterial drugs.

Synthesis, antimicrobial and molecular modeling studies of some benzophenone-based thiazole and 4-thiazolidinone derivatives

New series of thiazolyl hydrazones were designed and synthesized via the reaction of benzophenone thiosemicarbazone 2 with chloroacetic acid, (un)substituted phenacylbromide and ethyl-2-chloroacetoacetate to yield compounds 3, 5a-d & 6 respectively. Furth

Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the m

Antiaflatoxigenic Thiosemicarbazones as Crop-Protective Agents: A Cytotoxic and Genotoxic Study

Aflatoxins are secondary fungal metabolites that can contaminate feed and food. They are a cause of growing concern worldwide, because they are potent carcinogenic agents. Thiosemicarbazones are molecules that possess interesting antiaflatoxigenic propert

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis

A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure–activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties.

Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition

The group of 19 thiosemicarbazones (TSCs) were synthesized and its inhibitory activity toward mushroom tyrosinase and ability to inhibition of melanogenesis in B16 cells were investigated. Moreover, molecular docking of these compounds to the active site of the enzyme was performed. The obtained results allowed to make the structure-activity relationship (SAR) analysis. Kinetic studies revealed that TSCs 1, 2, 11 and 18 have better inhibitory properties than kojic acid, a reference compound, with the best inhibitory constant (Ki) value of 0.38 μM for TSC 2. According to SAR analysis, the smaller and less branched molecules exhibit higher affinity to the enzyme. Melanin production in B16 cells was inhibited by all investigated compounds at micromolar level. Most of compounds studied in this work can be considered as potent inhibitors of tyrosinase and melanogenesis. They may have broad application in food preservatives and cosmetics. Combined results of molecular docking and SAR analysis can be helpful in designing novel tyrosinase inhibitors of desired properties.

Design and synthesis of new benzophenone derivatives with in vivo anti-inflammatory activity through dual inhibition of edema and neutrophil recruitment

A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to examine their effect on both prostaglandin (PG) production and neutrophils recruitment. The thiazole derivatives displayed a potent effect in terms of reducing ear edema. The analysis suggested that the presence of 4-phenyl-2-hydrazinothiazole and the absence of C40-OCH3 on the benzophenone derivative structure are strongly related to the inhibition of PG production. In addition, the derivatives 2e, 3a and 3c concomitantly inhibit PG production and neutrophil recruitment, which may be a mechanism of action better than of common NSAIDs due to their inability to inhibit the neutrophil recruitment. Thus, these compounds can be considered as potential lead compounds toward the development of new anti-inflammatory drugs with an innovating mechanism of action.