73415-77-7Relevant academic research and scientific papers
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase
Xie, Yuli,Liu, Yidong,Gong, Gangli,Smith, Deborah H.,Yan, Fang,Rinderspacher, Alison,Feng, Yan,Zhu, Zhengxiang,Li, Xiangpo,Deng, Shi-Xian,Branden, Lars,Vidovic, Dusica,Chung, Caty,Schuerer, Stephan,Morisseau, Christophe,Hammock, Bruce D.,Landry, Donald W.
scheme or table, p. 2354 - 2359 (2009/12/07)
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.
4-Amino-2-piperidino-quinazolines
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, (2008/06/13)
Regulators of the cardiovascular system and, in particular, in the treatment of hypertension having the formula STR1 wherein R is lower alkyl; X, is a 3- or 4-position substituent and is --(CH2)n CONR1 R2, --O(C
