73422-62-5Relevant academic research and scientific papers
Practical synthesis of 4,4,4-trifluorocrotonaldehyde: A versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions
Shibatomi, Kazutaka,Narayama, Akira,Abe, Yoshiyuki,Iwasa, Seiji
, p. 7380 - 7382 (2012)
The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded t
